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Chemical Compound Review:

AG-J-62068 4-hydroxy-3-(3-methylbut-1...

Synonyms: SureCN9444176, CTK6A4297, CTK8I6075, AC1L63KH, NCIOpen2_005885

Lima, N.M. et al., dos Santos, A.F. et al.

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Disease relevance of NSC629755

Lapachol, isolapachol and nor-lapachol showed strong molluscicidal activity against the adult snail (LD(90)<10 ppm) and significant toxicity against snail egg masses (LD(90)<0.2 ppm) [1].

High impact information on NSC629755

All compounds presented significant activity, being isolapachol acetate the most active against promastigotes, with IC50/24h = 1.6 +/- 0.0 microg/ml and 3.4 +/- 0.5 microg/ml for, respectively, L. amazonensis and L. braziliensis [2].

References

Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives. dos Santos, A.F., Ferraz, P.A., Pinto, A.V., Pinto M do, C., Goulart, M.O., Sant'Ana, A.E. Int. J. Parasitol. (2000) [Pubmed]
Antileishmanial activity of lapachol analogues. Lima, N.M., Correia, C.S., Leon, L.L., Machado, G.M., Madeira, M.d.e. .F., Santana, A.E., Goulart, M.O. Mem. Inst. Oswaldo Cruz (2004) [Pubmed]

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