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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives.

In the search for new molluscicidal agents we tested the activity of lapachol and other 2-hydroxy-3-alkylnaphthoquinones possessing nitrogenated alkyl chains, against the snail Biomphalaria glabrata. Lapachol, isolapachol and nor-lapachol showed strong molluscicidal activity against the adult snail (LD(90)<10 ppm) and significant toxicity against snail egg masses (LD(90)<0.2 ppm). As lapachol is easily extracted, and the derivatives can be synthesised without any difficulty, large-scale synthesis and field tests can be conducted, with a view to large-scale molluscicidal programs.[1]

References

  1. Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives. dos Santos, A.F., Ferraz, P.A., Pinto, A.V., Pinto M do, C., Goulart, M.O., Sant'Ana, A.E. Int. J. Parasitol. (2000) [Pubmed]
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