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Chemical Compound Review:

CHEMBL163835 N-heptyl-N-methyl-nitrous amide

Synonyms: CCRIS 3061, LS-74732, AKOS006277375, BRN 2076926, AC1L1E1A, ...

Lijinsky, W. et al., Rehm, S. et al., Rehm, S. et al.

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Disease relevance of N-heptyl-N-methyl-nitrous amide

Squamous metaplasia of bronchiolar cell-derived adenocarcinoma induced by N-nitrosomethyl-n-heptylamine in Syrian hamsters [1].
Clara cell antigen in normal and migratory dysplastic Clara cells, and bronchioloalveolar carcinoma of Syrian hamsters induced by N-nitrosomethyl-n-heptylamine [2].

High impact information on N-heptyl-N-methyl-nitrous amide

In contrast, nitrosomethylheptylamine induced tumors of the liver and lung when given in drinking water or by gavage, but there were tumors of the esophagus only in those rats treated via the drinking water [3].

References

Squamous metaplasia of bronchiolar cell-derived adenocarcinoma induced by N-nitrosomethyl-n-heptylamine in Syrian hamsters. Rehm, S., Lijinsky, W. Vet. Pathol. (1994) [Pubmed]
Clara cell antigen in normal and migratory dysplastic Clara cells, and bronchioloalveolar carcinoma of Syrian hamsters induced by N-nitrosomethyl-n-heptylamine. Rehm, S., Lijinsky, W., Thomas, B.J., Kasprzak, B.H. Virchows Arch., B, Cell Pathol. (1993) [Pubmed]
Induction of tumors of the esophagus in rats by nitrosomethylalkylamines. Lijinsky, W., Reuber, M.D., Singer, G.M. J. Cancer Res. Clin. Oncol. (1983) [Pubmed]

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