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Chemical Compound Review: 

AC1MHZID     5-ethynyl-1-[(2S,4S,5R)-4- hydroxy-5...

Synonyms: 5'-Et-Dthd
 
 
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Disease relevance of 5'-Ethynylthymidine

  • At 100 microM 5'-ethynylthymidine, the cellular pool size of dTTP in herpes simplex virus type 1-infected cells was 5% that of infected cells receiving no drug treatment, while there was no significant effect on the pool sizes of dATP, dGTP, and dCTP [1].
 

High impact information on 5'-Ethynylthymidine

  • The levels of N-MCT-TP were significantly decreased in the presence of 5'-ethynylthymidine, a potent inhibitor of herpesvirus thymidine kinase, resulting in the abrogation of anti-KSHV activity of N-MCT [2].
  • 5'-Ethynylthymidine, an inhibitor of viral thymidine kinase (TK), was given intraperitoneally to squirrel monkeys previously infected by the ocular route with Rodanus strain herpes simplex virus [3].

References

  1. Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus. Nutter, L.M., Grill, S.P., Dutschman, G.E., Sharma, R.A., Bobek, M., Cheng, Y.C. Antimicrob. Agents Chemother. (1987) [Pubmed]
  2. Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus. Zhu, W., Burnette, A., Dorjsuren, D., Roberts, P.E., Huleihel, M., Shoemaker, R.H., Marquez, V.E., Agbaria, R., Sei, S. Antimicrob. Agents Chemother. (2005) [Pubmed]
  3. Suppression of ocular herpes recurrences by a thymidine kinase inhibitor in squirrel monkeys. Kaufman, H.E., Varnell, E.D., Cheng, Y.C., Bobek, M., Thompson, H.W., Dutschman, G.E. Antiviral Res. (1991) [Pubmed]
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