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Chemical Compound Review:

Neltenexine N-[2,4-dibromo-6-[[(4- hydroxycyclohexyl)am...

Synonyms: AC1MILTI, SureCN20299, AG-I-01722, CHEMBL2106972, SureCN10646479, ...

Cattaneo, C., Braga, P.C. et al.

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Disease relevance of Neltenexine

These experimental findings suggest that neltenexine might prove to be useful for preventing pulmonary emphysema [1].
Neltenexine: morphological investigation of protection against elastase-induced emphysema in rats [1].
BACKGROUND: The aim of this double-blind, randomised, controlled study vs placebo was to evaluate the efficacy and tolerability of neltenexine (tablets) versus placebo (tablets), administered to smoking and non-smoking patients with chronic obstructive pulmonary disease (COPD) [2].

High impact information on Neltenexine

CONCLUSIONS: The study confirmed earlier clinical experiences showing that neltenexine is effective in the treatment of COPD patients and highlighted the correlation between abstention from smoking and the efficacy of mucoactive treatment [2].
Furthermore, a significant improvement of the sputum characteristics (p<0.02) and volume (p<0.01) was evidenced, as compared with patients treated with placebo, in non smoking patients treated with neltenexine and in smoking patients treated with neltenexine [2].

References

Neltenexine: morphological investigation of protection against elastase-induced emphysema in rats. Braga, P.C., Piatti, G., Limoli, A., Dal Sasso, M., Maci, S. Drugs under experimental and clinical research. (1995) [Pubmed]
Neltenexine tablets in smoking and non-smoking patients with COPD. A double-blind, randomised, controlled study versus placebo. Cattaneo, C. Minerva Med. (2001) [Pubmed]

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