Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Razoxane 4-[1-(3,5-dioxopiperazin-1- yl)propan-2...

Synonyms: Razoxana, Cardioxan, Razoxin, ICRF-159, ICRF-186, ...

Herman, E.H. et al., Vogel, C.L. et al.

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Disease relevance of Razoxin

Adult beagle dogs were given doxorubicin (1.0 mg/kg body weight i.v.) either alone or 30 min after ICRF-187 (NSC 169780) (12.5 mg/kg body weight i.p.) at weekly intervals [1].

High impact information on Razoxin

Phase I clinical trial and pharmacokinetics of weekly ICRF-187 (NSC 169780) infusion in patients with solid tumors [2].

References

Reduction of chronic doxorubicin cardiotoxicity in dogs by pretreatment with (+/-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187). Herman, E.H., Ferrans, V.J. Cancer Res. (1981) [Pubmed]
Phase I clinical trial and pharmacokinetics of weekly ICRF-187 (NSC 169780) infusion in patients with solid tumors. Vogel, C.L., Gorowski, E., Davila, E., Eisenberger, M., Kosinski, J., Agarwal, R.P., Savaraj, N. Investigational new drugs. (1987) [Pubmed]

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