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Chemical Compound Review:

Nerispirdine N-(3-fluoropyridin-4-yl)-3- methyl-N-propyl...

Synonyms: AC1MIWGX, HP-184, CHEMBL2107762, SureCN3842518, DCL000837, ...

Smith, C.P. et al.

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Psychiatry related information on HP-184

Notably, HP 184 (15 mg/kg, i.p.) reduced drinking behavior in schedule-induced polydipsic (SIP) rats [1].

High impact information on HP-184

We report here that 100 microM HP 184 enhanced spontaneous release of [3H]serotonin (5-HT) from rat hippocampal slices [1].

Associations of HP-184 with other chemical compounds

In vivo assays confirmed that HP 184 (20 mg/kg, i.p.) lacked significant interactions at the norepinephrine (NE) or 5-HT uptake carrier itself [1].

References

Serotonergic activity of HP 184: does spontaneous release have a role? Smith, C.P., Woods-Kettelberger, A.T., Corbett, R., Chesson, S.M., Bores, G.M., Petko, W.W., Roehr, J.E., Kongsamut, S. Neurochem. Res. (1996) [Pubmed]

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