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Chemical Compound Review

Levophed     4-[(1S)-2-amino-1-hydroxy- ethyl]benzene-1...

Synonyms: Adrenor, Aktamin, Arterenol, Levonor, Levarterenol, ...
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Disease relevance of Levarterenol


Psychiatry related information on Levarterenol


High impact information on Levarterenol


Chemical compound and disease context of Levarterenol


Biological context of Levarterenol


Anatomical context of Levarterenol


Associations of Levarterenol with other chemical compounds


Gene context of Levarterenol

  • Both low- and high-frequency regulation seem to be physiologically important, as mice lacking both alpha2A- and alpha2C-receptor subtypes have elevated plasma noradrenaline concentrations and develop cardiac hypertrophy with decreased left ventricular contractility by four months of age [32].
  • Because (a) NPY has been shown to be colocalized with noradrenaline in peripheral as well as central catecholaminergic neurons, and (b) alpha 2-adrenergic receptors of adipocytes play a major role in the regulation of lipolysis, we investigated the effect of NPY and PYY on isolated fat cells [33].
  • Norepinephrine, likewise, caused a suppression of PRL secretion from adenomatous and nonadenomatous pituitary cells [34].
  • Noradrenaline (NA), a key neurotransmitter of the endogenous pain inhibitory system, acutely inhibits nociceptive transmission (including that mediated by substance P), potentiates opioid analgesia, and underlies part of the antinociceptive effects of the widely prescribed tricyclic antidepressants [35].
  • However, the ANS neurotransmitter norepinephrine enhanced replication of both CCR5- and CXCR4-tropic strains of HIV-1 in vitro via chemokine receptor up-regulation and enhanced viral gene expression, suggesting that neural activity may directly promote residual viral replication [36].
  • Among patients with chronic illness, carriers of the s allele of 5-HTTLPR are more vulnerable to depression, perceived stress, and high norepinephrine secretion [37].

Analytical, diagnostic and therapeutic context of Levarterenol


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