Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1MIX6Q N-[(2R,3R,4R,5R)-4- [(2S,3R,4R,5S,6R)-3...

Synonyms: 78392-29-7, Man(6)glcnac(2), Mannosyl(6)-N-acetylglucosamine(2)

Bewley, C.A. et al., Tempel, W. et al.

Bewley, Cai, Ray, Ghirlando, Yamaguchi, Muramoto,

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High impact information on Man(6)glcnac(2)

A Man(6)GlcNAc(2) oligosaccharide attached to Asn(515) in the murine enzyme was found to extend into the active site of an adjoining protein unit in the crystal lattice in a presumed enzyme-product complex [1].

Analytical, diagnostic and therapeutic context of Man(6)glcnac(2)

Here, we use NMR and isothermal titration calorimetry techniques to determine carbohydrate specificity and affinities for a novel cyanobacterial protein, MVL, and show that MVL binds oligomannosides such as Man(6)GlcNAc(2) with sub-micromolar affinities [2].

References

Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases. Tempel, W., Karaveg, K., Liu, Z.J., Rose, J., Wang, B.C., Moremen, K.W. J. Biol. Chem. (2004) [Pubmed]
New carbohydrate specificity and HIV-1 fusion blocking activity of the cyanobacterial protein MVL: NMR, ITC and sedimentation equilibrium studies. Bewley, C.A., Cai, M., Ray, S., Ghirlando, R., Yamaguchi, M., Muramoto, K. J. Mol. Biol. (2004) [Pubmed]

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