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Chemical Compound Review

CHEMBL283606     5-methoxy-N,N-dipropyl- chroman-3-amine

Synonyms: SureCN2217080, CHEBI:135888, AC1MIZ4R, CTK8G5655, DNC012100, ...
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High impact information on 5-Meo-dpac

  • Comparison of the chemical structures of 5-MeO-DPAC and other 5-HT1A ligands suggests that electronic enrichment due to isosteric O-substitution in the chroman derivative may play an important role in the highly selective recognition of the 5-HT1A receptor by this drug [1].
  • The decreased 5-hydroxytryptamine (5-HT) turnover may have resulted from activation of 5-HT receptors on cell bodies of 5-HT neurons that project to the striatum and other brain regions, since 5-MeO-DPAC had earlier been reported to lack affinity for striatal binding sites [2].


  1. The selective labelling of central 5-HT1A receptor binding sites by [3H]5-methoxy-3-(di-n-propylamino)chroman. Cossery, J.M., Gozlan, H., Spampinato, U., Perdicakis, C., Guillaumet, G., Pichat, L., Hamon, M. Eur. J. Pharmacol. (1987) [Pubmed]
  2. Decreased 5-hydroxytryptamine turnover in striatum and other brain regions after administration of 5-methoxy-3-(di-n-propylamino)chroman to rats. Fuller, R.W., Perry, K.W., Ward, J.S. J. Pharm. Pharmacol. (1989) [Pubmed]
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