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Chemical Compound Review

Glisepin     N-[2-[4-(azepan-1- ylcarbamoylsulfamoyl)phe...

Synonyms: Glisoxepid, Glisoxepida, Glisoxepide, Glisoxepidum, Pro-Diaban, ...
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High impact information on Glisoxepide

  • Glisoxepide uptake revealed two Km values: Km1 = 2-3 microM and Vmax1 = 200 pmol/mg protein per min, and Km2 = 110 microM and Vmax2 = 1600 pmol/mg protein per min [1].
  • Temperature dependence increased markedly beyond 22 degrees C and the apparent activation energy was 59.7 kJ/mol at low Km1 glisoxepide concentrations and 60.3 kJ/mol at high Km2 concentrations [1].
  • For diffusion at pH 7.4 the permeability coefficients were 3.3 x 10(-6) cm/s for glisoxepide and 10.6 x 10(-6) cm/s for glibenclamide [1].
  • The hepatic uptake of two sulfonylureas, glisoxepide and glibenclamide, was investigated in isolated rat hepatocytes [1].


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