Disease relevance of fipexide

• We describe three patients who developed fulminant hepatic failure less than 2 months after beginning fipexide administration [1].
• Treatment with fipexide was associated with a significant improvement in each and all monitored symptoms and signs to an average extent of 60%, whereas placebo was not [2].

Psychiatry related information on fipexide

• Piracetam and fipexide prevent PTZ-kindling-provoked amnesia in rats [3].
• Forty geriatric in-patients with severe cognition disorders were randomly allocated to treatment with either 600 mg fipexide daily or placebo over a period of 3 weeks [2].
• These results, along with our previous reports on fipexide effect on locomotor activity, allow us to hypothesize that the positive effect of this drug on cognitive performance seems to be mediated, at least partially, by dopaminergic neurotransmission [4].

High impact information on fipexide

• We conclude that fipexide can induce massive liver cell necrosis and fulminant liver failure [1].

Analytical, diagnostic and therapeutic context of fipexide

• Fipexide-induced fulminant hepatitis. Report of three cases with emergency liver transplantation [1].

References