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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

NSC-523236     2-(3-hydroxy-10,13-dimethyl- 2,3,4,7,8,9,11...

Synonyms: CTK8H4343, NSC523236, AC1L6Z1B, 19243-30-2, 22-Ketocholesterol, ...
 
 
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High impact information on NSC523236

  • On the basis of recently proposed mechanisms for hydroxylation by cytochromes P-450, 22-ketocholesterol may exert its inhibitory effect by acting as a tightly bound analogue that resembles the enzyme-bound cholesterol from which a hydrogen has been abstracted from position 22 [1].
  • Steric considerations regarding the biodegradation of cholesterol to pregnenolone.-exclusion of (22S)-22-hydroxycholesterol and 22-ketocholesterol as intermediates [2].

References

  1. 22-Ketocholesterol. A potent competitive inhibitor of cytochrome P-450scc-dependent side-chain cleavage of cholesterol. Lambeth, J.D. Mol. Pharmacol. (1983) [Pubmed]
  2. Steric considerations regarding the biodegradation of cholesterol to pregnenolone.-exclusion of (22S)-22-hydroxycholesterol and 22-ketocholesterol as intermediates. Byon, C.Y., Gut, M. Biochem. Biophys. Res. Commun. (1980) [Pubmed]
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