Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Dolastatin 11 (2S,8S,14S,17S,20S,25S,28R,29S )-2-[(2S)...

Synonyms: CHEMBL507131, NSC-606195, NSC606195, AC1L748X, NCI60_004658, ...

Oda, T. et al., Bai, R. et al.

Oda, Crane, Dicus, Sufi, Bates,

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High impact information on Dolastatin 11

However, according to the previous biochemical study, the binding of dolastatin 11 to F-actin does not compete with that of phalloidin, suggesting that the binding sites are different [1].
Dolastatin 11 connects two long-pitch strands in F-actin to stabilize microfilaments [1].

Biological context of Dolastatin 11

Thus, despite its structural similarity to other agents that induce actin assembly (all are peptides or depsipeptides), dolastatin 11 may interact with actin polymers at a distinct drug binding site [2].

References

Dolastatin 11 connects two long-pitch strands in F-actin to stabilize microfilaments. Oda, T., Crane, Z.D., Dicus, C.W., Sufi, B.A., Bates, R.B. J. Mol. Biol. (2003) [Pubmed]
Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin. Bai, R., Verdier-Pinard, P., Gangwar, S., Stessman, C.C., McClure, K.J., Sausville, E.A., Pettit, G.R., Bates, R.B., Hamel, E. Mol. Pharmacol. (2001) [Pubmed]

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