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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Microfilaments

 
 
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Disease relevance of Microfilaments

 

Psychiatry related information on Microfilaments

  • These findings suggest that actin filaments play a role in modulating [Ca2+]i responses to neurotoxic insults and that depolymerization of actin can protect neurons against insults relevant to the pathogenesis of Alzheimer's disease [6].
 

High impact information on Microfilaments

 

Chemical compound and disease context of Microfilaments

 

Biological context of Microfilaments

 

Anatomical context of Microfilaments

  • Double immunolabeling revealed that newly assembled keratin was not codistributed with microfilament bundles, microtubules or vimentin filaments [21].
  • These results suggested that vinculin interacts with a specific site located at the growing ends of actin filaments in a cytochalasin-like manner, a property consistent with its proposed function as a linkage protein between filaments and the plasma membranes [16].
  • The fibronexus: a transmembrane association of fibronectin-containing fibers and bundles of 5 nm microfilaments in hamster and human fibroblasts [22].
  • We have studied the mechanism of Ca++-dependent restriction of actin filament length by villin, one of the major actin-associated proteins of intestinal microvilli microfilament bundles [23].
  • We propose a model for selection of lamellipodial versus filopodial organization in which CP is a negative regulator of filopodia formation and Ena/VASP has recruiting/activating functions downstream of actin filament elongation in addition to its previously suggested anticapping and antibranching activities [24].
 

Associations of Microfilaments with chemical compounds

 

Gene context of Microfilaments

 

Analytical, diagnostic and therapeutic context of Microfilaments

References

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  10. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Drees, F., Pokutta, S., Yamada, S., Nelson, W.J., Weis, W.I. Cell (2005) [Pubmed]
  11. Microtubules and microfilaments in fixed and permeabilized cells are selectively decorated by nerve growth factor. Nasi, S., Cirillo, D., Naldini, L., Marchisio, P.C., Calissano, P. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
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  14. Surface molecule loss and bleb formation by human germinal center B cells undergoing apoptosis: role of apoptotic blebs in monocyte chemotaxis. Segundo, C., Medina, F., Rodríguez, C., Martínez-Palencia, R., Leyva-Cobián, F., Brieva, J.A. Blood (1999) [Pubmed]
  15. The effect of an isovolumic left ventricle on the coronary vascular competence during reflow after global ischemia in the rat heart. Humphrey, S.M., Thomson, R.W., Gavin, J.B. Circ. Res. (1981) [Pubmed]
  16. High-affinity interaction of vinculin with actin filaments in vitro. Wilkins, J.A., Lin, S. Cell (1982) [Pubmed]
  17. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Witke, W., Sharpe, A.H., Hartwig, J.H., Azuma, T., Stossel, T.P., Kwiatkowski, D.J. Cell (1995) [Pubmed]
  18. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Arber, S., Barbayannis, F.A., Hanser, H., Schneider, C., Stanyon, C.A., Bernard, O., Caroni, P. Nature (1998) [Pubmed]
  19. Phosphorylation of non-muscle caldesmon by p34cdc2 kinase during mitosis. Yamashiro, S., Yamakita, Y., Hosoya, H., Matsumura, F. Nature (1991) [Pubmed]
  20. The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Peng, C.Y., Manning, L., Albertson, R., Doe, C.Q. Nature (2000) [Pubmed]
  21. De novo synthesis and specific assembly of keratin filaments in nonepithelial cells after microinjection of mRNA for epidermal keratin. Kreis, T.E., Geiger, B., Schmid, E., Jorcano, J.L., Franke, W.W. Cell (1983) [Pubmed]
  22. The fibronexus: a transmembrane association of fibronectin-containing fibers and bundles of 5 nm microfilaments in hamster and human fibroblasts. Singer, I.I. Cell (1979) [Pubmed]
  23. F actin assembly modulated by villin: Ca++-dependent nucleation and capping of the barbed end. Glenney, J.R., Kaulfus, P., Weber, K. Cell (1981) [Pubmed]
  24. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Mejillano, M.R., Kojima, S., Applewhite, D.A., Gertler, F.B., Svitkina, T.M., Borisy, G.G. Cell (2004) [Pubmed]
  25. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Maness, P.F., Walsh, R.C. Cell (1982) [Pubmed]
  26. Early changes in the distribution and organization of microfilament proteins during cell transformation. Boschek, C.B., Jockusch, B.M., Friis, R.R., Back, R., Grundmann, E., Bauer, H. Cell (1981) [Pubmed]
  27. Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts. Willingham, M.C., Yamada, K.M., Yamada, S.S., Pouysségur, J., Pastan, I. Cell (1977) [Pubmed]
  28. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Hartwig, J.H., Bokoch, G.M., Carpenter, C.L., Janmey, P.A., Taylor, L.A., Toker, A., Stossel, T.P. Cell (1995) [Pubmed]
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  30. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Gertler, F.B., Niebuhr, K., Reinhard, M., Wehland, J., Soriano, P. Cell (1996) [Pubmed]
  31. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Miki, H., Sasaki, T., Takai, Y., Takenawa, T. Nature (1998) [Pubmed]
  32. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Pashmforoush, M., Pomiès, P., Peterson, K.L., Kubalak, S., Ross, J., Hefti, A., Aebi, U., Beckerle, M.C., Chien, K.R. Nat. Med. (2001) [Pubmed]
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  35. Nerve growth factor triggers microfilament assembly and paxillin phosphorylation in human B lymphocytes. Melamed, I., Turner, C.E., Aktories, K., Kaplan, D.R., Gelfand, E.W. J. Exp. Med. (1995) [Pubmed]
  36. Anticytoskeletal autoantibody to microfilament anchorage sites recognizes novel focal contact proteins. Senécal, J.L., Fortin, S., Roussin, A., Joyal, F. J. Clin. Invest. (1987) [Pubmed]
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