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Chemical Compound Review:

PubChem24179 1-(2-ethanoylphenyl)ethanone

Synonyms: SureCN279655, AG-G-74864, ACMC-20ap6r, FR-2167, AC1L1TPR, ...

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Disease relevance of EINECS 211-877-6

The aromatic gamma-diketone 1,2-diacetylbenzene (1,2-DAB), the putative active metabolite of the organic solvent 1,2-diethylbenzene, forms blue-colored polymeric protein adducts and induces the formation of amyotrophic lateral sclerosis (ALS)-like giant, intraspinal neurofilamentous axonal swellings in Sprague Dawley rats [1].

High impact information on EINECS 211-877-6

The chromogenic and neurotoxic gamma-diketone 1,2-diacetylbenzene (1,2-DAB), but not its isomer 1,3-DAB, induces blue discoloration of tissues and urine, clustering of axonal microtubules and proximal neurofilament-filled axonal swellings in rodents [2].
A liquid chromatographic-mass spectrometric method to evaluate the distribution kinetics of 1,2-diethylbenzene and its metabolite 1,2-diacetylbenzene in the F344 male rat [3].
Male Sprague-Dawley rats were treated either with 1,2-diethylbenzene (1,2-DEB) or its putative active metabolite, 1,2-diacetylbenzene (1,2-DAB) [4].

References

A new murine model of giant proximal axonopathy. Tshala-Katumbay, D.D., Palmer, V.S., Kayton, R.J., Sabri, M.I., Spencer, P.S. Acta Neuropathol. (2005) [Pubmed]
Monocyclic and dicyclic hydrocarbons: structural requirements for proximal giant axonopathy. Tshala-Katumbay, D.D., Palmer, V.S., Lasarev, M.R., Kayton, R.J., Sabri, M.I., Spencer, P.S. Acta Neuropathol. (2006) [Pubmed]
A liquid chromatographic-mass spectrometric method to evaluate the distribution kinetics of 1,2-diethylbenzene and its metabolite 1,2-diacetylbenzene in the F344 male rat. Thrall, K.D., Gies, R.A., Cartmell, A.M., Wu, H., Soelberg, J.J., Klein, J.A. J. Toxicol. Environ. Health Part A (2007) [Pubmed]
Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene-treated rats. Gagnaire, F., Becker, M.N., De Ceaurriz, J. Journal of applied toxicology : JAT. (1992) [Pubmed]

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