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Chemical Compound Review:

Diethylbenzol 1,2-diethylbenzene

Synonyms: DIETHYLBENZENE, ACMC-1CH19, D90601_ALDRICH, AG-D-71696, HSDB 4081, ...

Gagnaire, F. et al., Roshchin, T.M. et al., Payan, J.P. et al., Thrall, K.D. et al., Gagnaire, F. et al., et al.

Payan, Cossec, Beydon, Fabry, Ferrari, Thrall, Gies, Cartmell, Wu, Soelberg, Klein, Payan, Beydon, Cossec, Ensminger, Fabry, Ferrari,

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Disease relevance of HSDB 4081

Assessment of the developmental toxicity and placental transfer of 1,2-diethylbenzene in rats [1].

High impact information on HSDB 4081

Toxicokinetics and metabolism of 1,2-diethylbenzene in male Sprague Dawley rats--part 2: evidence for in vitro and in vivo stereoselectivity of 1,2-diethylbenzene metabolism [2].
A liquid chromatographic-mass spectrometric method to evaluate the distribution kinetics of 1,2-diethylbenzene and its metabolite 1,2-diacetylbenzene in the F344 male rat [3].
Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene-treated rats [4].
Motor and sensory conduction velocities (MCV and SCV), amplitude of the sensory action potential (ASAP) of the tail nerve and parameters of brainstem auditory evoked potentials (BAEP) were studied in male Sprague-Dawley rats after prolonged inhalation exposure to a commercial isomer mixture of diethylbenzene (DEB mixture) containing 6% 1,2-DEB [5].

Chemical compound and disease context of HSDB 4081

The role of 1,2-diacetylbenzene (1,2-DAB) in the peripheral nerve toxicity of 1,2-diethylbenzene (1,2-DEB) was investigated in rats [6].

Biological context of HSDB 4081

Toxicokinetics of 1,2-diethylbenzene in male Sprague-Dawley rats-part 1: excretion and metabolism of [(14)C]1,2-diethylbenzene [7].

Anatomical context of HSDB 4081

Diethylbenzene inhalation-induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potentials in rats [5].

Analytical, diagnostic and therapeutic context of HSDB 4081

Adsorption of small organic compounds (n-alkanes, alkylbenzene, benzene, diethyl ether) was investigated using two methods, classical static adsorption and gas chromatography [8].
A benzene-diethyl ether-cyclohexane (5:3:2, v/v/v) solvent system was used for quantitative evaluation of chromatograms [9].

References

Assessment of the developmental toxicity and placental transfer of 1,2-diethylbenzene in rats. Saillenfait, A.M., Payan, J.P., Langonné, I., Gallissot, F., Sabaté, J.P., Beydon, D., Fabry, J.P. Food Chem. Toxicol. (1999) [Pubmed]
Toxicokinetics and metabolism of 1,2-diethylbenzene in male Sprague Dawley rats--part 2: evidence for in vitro and in vivo stereoselectivity of 1,2-diethylbenzene metabolism. Payan, J.P., Cossec, B., Beydon, D., Fabry, J.P., Ferrari, E. Drug Metab. Dispos. (2001) [Pubmed]
A liquid chromatographic-mass spectrometric method to evaluate the distribution kinetics of 1,2-diethylbenzene and its metabolite 1,2-diacetylbenzene in the F344 male rat. Thrall, K.D., Gies, R.A., Cartmell, A.M., Wu, H., Soelberg, J.J., Klein, J.A. J. Toxicol. Environ. Health Part A (2007) [Pubmed]
Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene-treated rats. Gagnaire, F., Becker, M.N., De Ceaurriz, J. Journal of applied toxicology : JAT. (1992) [Pubmed]
Diethylbenzene inhalation-induced electrophysiological deficits in peripheral nerves and changes in brainstem auditory evoked potentials in rats. Gagnaire, F., Becker, M.N., Marignac, B., Bonnet, P., De Ceaurriz, J. Journal of applied toxicology : JAT. (1992) [Pubmed]
Possible involvement of 1,2-diacetylbenzene in diethylbenzene-induced neuropathy in rats. Gagnaire, F., Ensminger, A., Marignac, B., De Ceaurriz, J. Journal of applied toxicology : JAT. (1991) [Pubmed]
Toxicokinetics of 1,2-diethylbenzene in male Sprague-Dawley rats-part 1: excretion and metabolism of [(14)C]1,2-diethylbenzene. Payan, J.P., Beydon, D., Cossec, B., Ensminger, A., Fabry, J.P., Ferrari, E. Drug Metab. Dispos. (1999) [Pubmed]
Adsorption study of alkyl-silicas and methylsiloxy-silicas. Roshchin, T.M., Shonia, N.K., Kazmina, A.A., Gurevich, K.B., Fadeev, A.Y. Journal of chromatography. A. (2001) [Pubmed]
Determination of some insect repellents in cosmetic products by high-performance thin-layer chromatography. Markovic, G., Agbaba, D., Stakic, D.Z., Vladimirov, S. Journal of chromatography. A. (1999) [Pubmed]

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