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Chemical Compound Review

SureCN381084     1,2-dihydronaphthalene-1,2- diol

Synonyms: AG-J-01199, CHEBI:28516, KST-1B8332, AC1Q7AUA, KB-10139, ...
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Disease relevance of C06205


High impact information on C06205


Associations of C06205 with other chemical compounds

  • CONCLUSIONS: The findings showed that the progression rate of ND-induced cataract correlated with the level of lens AR and ND, indicating that AR was the key enzyme for the metabolism of ND in the process of naphthalene cataract development [3].

Gene context of C06205

  • Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors [4].
  • The stoichiometry of 1:1 between the consumption of ND and the formation of NADH for the formation of HNQ implies that rat lens aldose reductase catalyzes a 2e- oxidation of ND to yield the corresponding ketol, which is autoxidized to NQ [1].

Analytical, diagnostic and therapeutic context of C06205


  1. Aldose reductase catalyzes the oxidation of naphthalene-1, 2-dihydrodiol for the formation of ortho-naphthoquinone. Sugiyama, K., Wang, T.C., Simpson, J.T., Rodriguez, L., Kador, P.F., Sato, S. Drug Metab. Dispos. (1999) [Pubmed]
  2. Effects of naphthalene metabolites on cultured cells from eye lens. Russell, P., Yamada, T., Xu, G.T., Garland, D., Zigler, J.S. Free Radic. Biol. Med. (1991) [Pubmed]
  3. Involvement of aldose reductase in naphthalene cataract. Lee, A.Y., Chung, S.S. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  4. Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors. Sato, S., Sugiyama, K., Lee, Y.S., Kador, P.F. Exp. Eye Res. (1999) [Pubmed]
  5. Inhibition of endothelial nitric oxide synthase activity and suppression of endothelium-dependent vasorelaxation by 1,2-naphthoquinone, a component of diesel exhaust particles. Sun, Y., Taguchi, K., Sumi, D., Yamano, S., Kumagai, Y. Arch. Toxicol. (2006) [Pubmed]
  6. Stereochemistry and evidence for an arene oxide-NIH shift pathway in the fungal metabolism of naphthalene. Cerniglia, C.E., Althaus, J.R., Evans, F.E., Freeman, J.P., Mitchum, R.K., Yang, S.K. Chem. Biol. Interact. (1983) [Pubmed]
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