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Chemical Compound Review

Mefoxitin     sodium(6S,7S)-3- (aminocarbonyloxymethyl)...

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Disease relevance of (6S,7R)-3-(aminocarbonyloxymethyl)-7-methoxy-8-oxo-7-(2-thiophen-2-ylethanoylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Of 152 patients who were scheduled for an amputation for ischemia, seventy-seven were randomly assigned to perioperative prophylaxis with cefoxitin (Mefoxin) and seventy-five patients, to injections of a placebo [1].


  1. Prophylactic antibiotics in amputation of the lower extremity for ischemia. A placebo-controlled, randomized trial of cefoxitin. Sonne-Holm, S., Boeckstyns, M., Menck, H., Sinding, A., Leicht, P., Dichmann, O., Prag, J.B., Baekgaard, N., Ostri, P., Gøtrik, J.K. The Journal of bone and joint surgery. American volume. (1985) [Pubmed]
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