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Chemical Compound Review

Lorafem     7-[(2-amino-2-phenyl- ethanoyl)amino]-3...

Synonyms: Loribid, Loracarbefum, CHEMBL1013, AGN-PC-00JZRF, CHEMBL214386, ...
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Disease relevance of loracarbef


High impact information on loracarbef

  • The aim of this study was to evaluate whether pre-exposure of bacteria to a subinhibitory concentration (sub-MIC) of loracarbef (LY 163892) or daptomycin (LY 146032) could modify bacterial susceptibility to serum bactericidal activity and to phagocytosis and killing by murine peritoneal macrophages and by human polymorphonuclear leucocytes [2].


  1. General pharmacology of loracarbef in animals. Shetler, T., Bendele, A., Buening, M., Clemens, J., Colbert, W., Deldar, A., Helton, D., McGrath, J., Shannon, H., Turk, J. Arzneimittel-Forschung. (1993) [Pubmed]
  2. Influence of subinhibitory concentrations of loracarbef (LY 163892) and daptomycin (LY 146032) on bacterial phagocytosis, killing and serum sensitivity. Tripodi, M.F., Adinolfi, L.E., Utili, R., Marrone, A., Ruggiero, G. J. Antimicrob. Chemother. (1990) [Pubmed]
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