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Chemical Compound Review:

Lorafem 7-[(2-amino-2-phenyl- ethanoyl)amino]-3...

Synonyms: Loribid, Loracarbefum, CHEMBL1013, AGN-PC-00JZRF, CHEMBL214386, ...

Tripodi, M.F. et al., Shetler, T. et al.

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Disease relevance of loracarbef

Loracarbef ((6R, 7S)-7-[(R)-2-amino-2-phenyl-acetamido]-3-chloro-8-oxo-1- azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid, monohydrate, LY 163892, CAS 121961-22-6) is a carbacephem antibiotic targeted for use in the treatment of infectious disease [1].

High impact information on loracarbef

The aim of this study was to evaluate whether pre-exposure of bacteria to a subinhibitory concentration (sub-MIC) of loracarbef (LY 163892) or daptomycin (LY 146032) could modify bacterial susceptibility to serum bactericidal activity and to phagocytosis and killing by murine peritoneal macrophages and by human polymorphonuclear leucocytes [2].

References

General pharmacology of loracarbef in animals. Shetler, T., Bendele, A., Buening, M., Clemens, J., Colbert, W., Deldar, A., Helton, D., McGrath, J., Shannon, H., Turk, J. Arzneimittel-Forschung. (1993) [Pubmed]
Influence of subinhibitory concentrations of loracarbef (LY 163892) and daptomycin (LY 146032) on bacterial phagocytosis, killing and serum sensitivity. Tripodi, M.F., Adinolfi, L.E., Utili, R., Marrone, A., Ruggiero, G. J. Antimicrob. Chemother. (1990) [Pubmed]

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