The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Phagocytosis


Psychiatry related information on Phagocytosis


High impact information on Phagocytosis

  • (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila [10].
  • Surfactant proteins A and D (SP-A and SP-D) are lung collectins composed of two regions, a globular head domain that binds PAMPs and a collagenous tail domain that initiates phagocytosis [11].
  • However, interaction of these heads with PAMPs on foreign organisms or damaged cells and presentation of the collagenous tails in an aggregated state to calreticulin/CD91, stimulates phagocytosis and proinflammatory responses [11].
  • In mammalian cells, ELMO1 functionally cooperates with CrkII and Dock180 to promote phagocytosis and cell shape changes [12].
  • Coronin involved in phagocytosis: dynamics of particle-induced relocalization visualized by a green fluorescent protein Tag [13].

Chemical compound and disease context of Phagocytosis


Biological context of Phagocytosis


Anatomical context of Phagocytosis


Associations of Phagocytosis with chemical compounds


Gene context of Phagocytosis

  • Taken together with available morphologic and biochemical information, these findings are consistent with a mechanism wherein interactions of actin, ABP and myosin redistribute cortical cytoplasm into pseudopods involved in locomotion and phagocytosis [23].
  • Neutrophils carry Fc receptor II (FcRII; CDw32) and FcRIII (CD16) which both bind IgG-containing immune complexes, leading to phagocytosis of the complex and activation of the neutrophil [31].
  • Here we show that apoptotic cells interact with CD14, triggering phagocytosis of the apoptotic cells [32].
  • MBL binds to specific carbohydrate structures found on the surface of a range of microorganisms, including bacteria, yeasts, parasitic protozoa and viruses, and exhibits antibacterial activity through killing mediated by the terminal, lytic complement components or by promoting phagocytosis [33].
  • A co-stimulatory signal through ICAM-beta2 integrin-binding potentiates neutrophil phagocytosis [34].

Analytical, diagnostic and therapeutic context of Phagocytosis


  1. Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Kocks, C., Cho, J.H., Nehme, N., Ulvila, J., Pearson, A.M., Meister, M., Strom, C., Conto, S.L., Hetru, C., Stuart, L.M., Stehle, T., Hoffmann, J.A., Reichhart, J.M., Ferrandon, D., Rämet, M., Ezekowitz, R.A. Cell (2005) [Pubmed]
  2. Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Freire-de-Lima, C.G., Nascimento, D.O., Soares, M.B., Bozza, P.T., Castro-Faria-Neto, H.C., de Mello, F.G., DosReis, G.A., Lopes, M.F. Nature (2000) [Pubmed]
  3. Increased resistance to Staphylococcus aureus infection and enhancement in serum lysozyme activity by glucan. Kokoshis, P.L., Williams, D.L., Cook, J.A., Di Luzio, N.R. Science (1978) [Pubmed]
  4. Opsonin-independent ligation of Fc gamma receptors. The 3G8-bearing receptors on neutrophils mediate the phagocytosis of concanavalin A-treated erythrocytes and nonopsonized Escherichia coli. Salmon, J.E., Kapur, S., Kimberly, R.P. J. Exp. Med. (1987) [Pubmed]
  5. Inhibition of complement-mediated opsonization and phagocytosis of Streptococcus pyogenes by D fragments of fibrinogen and fibrin bound to cell surface M protein. Whitnack, E., Beachey, E.H. J. Exp. Med. (1985) [Pubmed]
  6. Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. Webster, S.D., Galvan, M.D., Ferran, E., Garzon-Rodriguez, W., Glabe, C.G., Tenner, A.J. J. Immunol. (2001) [Pubmed]
  7. Functional characterization of peripheral circulating and liver recruited neutrophils in endotoxic rats. Spitzer, J.A., Zhang, P., Mayer, A.M. J. Leukoc. Biol. (1994) [Pubmed]
  8. Enhanced prostaglandin E2 and thromboxane B2 release from resident peritoneal macrophages isolated from morphine-dependent rats. Elliott, G.R., van Batenburg, M.J., Dzoljic, M.R. FEBS Lett. (1987) [Pubmed]
  9. Administration of thymopentin to patients with phobic disorders improves depressed phagocytic functions. Covelli, V., Munno, I., Altamura, M., Pellegrino, N.M., Decandia, P., Jirillo, E. Immunopharmacology and immunotoxicology. (1990) [Pubmed]
  10. Eater: a big bite into phagocytosis. Ertürk-Hasdemir, D., Silverman, N. Cell (2005) [Pubmed]
  11. By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Gardai, S.J., Xiao, Y.Q., Dickinson, M., Nick, J.A., Voelker, D.R., Greene, K.E., Henson, P.M. Cell (2003) [Pubmed]
  12. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Gumienny, T.L., Brugnera, E., Tosello-Trampont, A.C., Kinchen, J.M., Haney, L.B., Nishiwaki, K., Walk, S.F., Nemergut, M.E., Macara, I.G., Francis, R., Schedl, T., Qin, Y., Van Aelst, L., Hengartner, M.O., Ravichandran, K.S. Cell (2001) [Pubmed]
  13. Coronin involved in phagocytosis: dynamics of particle-induced relocalization visualized by a green fluorescent protein Tag. Maniak, M., Rauchenberger, R., Albrecht, R., Murphy, J., Gerisch, G. Cell (1995) [Pubmed]
  14. Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells. Schlondorff, D., Satriano, J.A., Hagege, J., Perez, J., Baud, L. J. Clin. Invest. (1984) [Pubmed]
  15. Deficiency of a surface membrane glycoprotein (Mo1) in man. Dana, N., Todd, R.F., Pitt, J., Springer, T.A., Arnaout, M.A. J. Clin. Invest. (1984) [Pubmed]
  16. Potentiation of opsonization and phagocytosis of Streptococcus pyogenes following growth in the presence of clindamycin. Gemmell, C.G., Peterson, P.K., Schmeling, D., Kim, Y., Mathews, J., Wannamaker, L., Quie, P.G. J. Clin. Invest. (1981) [Pubmed]
  17. Phagocyte-derived lactate stimulates oxygen consumption by Neisseria gonorrhoeae. An unrecognized aspect of the oxygen metabolism of phagocytosis. Britigan, B.E., Klapper, D., Svendsen, T., Cohen, M.S. J. Clin. Invest. (1988) [Pubmed]
  18. Vi polysaccharide of Salmonella typhi targets the prohibitin family of molecules in intestinal epithelial cells and suppresses early inflammatory responses. Sharma, A., Qadri, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  19. Surface functions during Mitosis I: phagocytosis, pinocytosis and mobility of surface-bound Con A. Berlin, R.D., Oliver, J.M., Walter, R.J. Cell (1978) [Pubmed]
  20. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Savill, J., Dransfield, I., Hogg, N., Haslett, C. Nature (1990) [Pubmed]
  21. Identification of a factor that links apoptotic cells to phagocytes. Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., Nagata, S. Nature (2002) [Pubmed]
  22. Malakoplakia: evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo. Abdou, N.I., NaPombejara, C., Sagawa, A., Ragland, C., Stechschulte, D.J., Nilsson, U., Gourley, W., Watanabe, I., Lindsey, N.J., Allen, M.S. N. Engl. J. Med. (1977) [Pubmed]
  23. Distribution of actin-binding protein and myosin in polymorphonuclear leukocytes during locomotion and phagocytosis. Valerius, N.H., Stendahl, O., Hartwig, J.H., Stossel, T.P. Cell (1981) [Pubmed]
  24. Prostaglandin synthesis in different phases of phagocytosis in lung macrophages. Hsueh, W., Gonzalez-Crussi, F., Hanneman, E. Nature (1980) [Pubmed]
  25. Release of eosinophil chemotactic factor from human polymorphonuclear neutrophils by calcium ionophore A23187 and phagocytosis. Gzarnetzki, B.M., Konig, W., Lichtenstein, L.M. Nature (1975) [Pubmed]
  26. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nieuwenhuis, E.E., Matsumoto, T., Exley, M., Schleipman, R.A., Glickman, J., Bailey, D.T., Corazza, N., Colgan, S.P., Onderdonk, A.B., Blumberg, R.S. Nat. Med. (2002) [Pubmed]
  27. Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc. Herr, A.B., Ballister, E.R., Bjorkman, P.J. Nature (2003) [Pubmed]
  28. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Fadok, V.A., Bratton, D.L., Rose, D.M., Pearson, A., Ezekewitz, R.A., Henson, P.M. Nature (2000) [Pubmed]
  29. Compartmentalization of cyclic AMP during phagocytosis by human neutrophilic granulocytes. Pryzwansky, K.B., Steiner, A.L., Spitznagel, J.K., Kapoor, C.L. Science (1981) [Pubmed]
  30. Phagocytosis: flow cytometric quantitation with fluorescent microspheres. Steinkamp, J.A., Wilson, J.S., Saunders, G.C., Stewart, C.C. Science (1982) [Pubmed]
  31. The PI-linked receptor FcRIII is released on stimulation of neutrophils. Huizinga, T.W., van der Schoot, C.E., Jost, C., Klaassen, R., Kleijer, M., von dem Borne, A.E., Roos, D., Tetteroo, P.A. Nature (1988) [Pubmed]
  32. Human CD14 mediates recognition and phagocytosis of apoptotic cells. Devitt, A., Moffatt, O.D., Raykundalia, C., Capra, J.D., Simmons, D.L., Gregory, C.D. Nature (1998) [Pubmed]
  33. A second serine protease associated with mannan-binding lectin that activates complement. Thiel, S., Vorup-Jensen, T., Stover, C.M., Schwaeble, W., Laursen, S.B., Poulsen, K., Willis, A.C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K.B., Jensenius, J.C. Nature (1997) [Pubmed]
  34. A co-stimulatory signal through ICAM-beta2 integrin-binding potentiates neutrophil phagocytosis. Schnitzler, N., Haase, G., Podbielski, A., Lütticken, R., Schweizer, K.G. Nat. Med. (1999) [Pubmed]
  35. Phagocytic chimeric receptors require both transmembrane and cytoplasmic domains from the mannose receptor. Kruskal, B.A., Sastry, K., Warner, A.B., Mathieu, C.E., Ezekowitz, R.A. J. Exp. Med. (1992) [Pubmed]
  36. A molecular mechanism of integrin crosstalk: alphavbeta3 suppression of calcium/calmodulin-dependent protein kinase II regulates alpha5beta1 function. Blystone, S.D., Slater, S.E., Williams, M.P., Crow, M.T., Brown, E.J. J. Cell Biol. (1999) [Pubmed]
  37. Initial events during phagocytosis by macrophages viewed from outside and inside the cell: membrane-particle interactions and clathrin. Aggeler, J., Werb, Z. J. Cell Biol. (1982) [Pubmed]
  38. Barrier cells in the spleen. Weiss, L. Immunol. Today (1991) [Pubmed]
  39. Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome. Simms, H.H., D'Amico, R. Blood (1994) [Pubmed]
WikiGenes - Universities