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Chemical Compound Review

CHEMBL417844     N,N'-dibuta-2,3-dienylbutane- 1,4-diamine

Synonyms: ANW-53654, CPD-10696, CHEBI:140378, MDL72527, AK-38684, ...
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Disease relevance of MDL72527

  • In contrast, the combination of N(1), N(11)-diethylnorspermine with MDL72527 dramatically activated SSAT, causing profound depletion of pancreatic polyamines and acute pancreatitis [1].

High impact information on MDL72527

  • Administration of specific PAO inhibitor, MDL72527 [N(1),N(2)-bis(2,3-butadienyl)-1,4-butanediamine], however, did not affect the histological score of the pancreatitis [1].
  • This back-conversion was only partly inhibited by MDL72527, an inhibitor of polyamine oxidase [2].
  • The structure of PAO in complex with the inhibitor MDL72527 reveals the residues forming the catalytic machinery and unusual enzyme-inhibitor CH.O H bonds [3].
  • Three days after treatment, sucrase and maltase activity was higher in rats treated with spermine and MDL72527 than that in animals receiving spermine alone [4].


  1. Activation of polyamine catabolism in transgenic rats induces acute pancreatitis. Alhonen, L., Parkkinen, J.J., Keinanen, T., Sinervirta, R., Herzig, K.H., Jänne, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues. Niiranen, K., Pietilä, M., Pirttilä, T.J., Järvinen, A., Halmekytö, M., Korhonen, V.P., Keinänen, T.A., Alhonen, L., Jänne, J. J. Biol. Chem. (2002) [Pubmed]
  3. A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase. Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P., Mattevi, A. Structure (1999) [Pubmed]
  4. Analysis of structural and biochemical events occurring in the small intestine after dietary polyamine ingestion in suckling rats. Kaouass, M., Deloyer, P., Wery, I., Dandrifosse, G. Dig. Dis. Sci. (1996) [Pubmed]
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