Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L8OLJ 7-[4-(dibenzylamino)-5- hydroxy-6-methyl...

Synonyms: 69230-47-3, N,N-Dibenzyldaunorubicin

Acton, E.M., Tong, G.L. et al., Marsh, J.C. et al.

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Disease relevance of NSC268242

A dose of 200 mg/sq m of N,N-dibenzyldaunorubicin would be expected to produce moderate leukopenia in future clinical trials [1].
N,N-Dibenzyldaunorubicin was especially notable for increased efficacy (T/C 259, qd 1--9) against P388 leukemia in mice, despite reduction of DNA binding in vitro [2].

High impact information on NSC268242

N,N-Dibenzyldaunorubicin is an inactive prodrug requiring metabolic activation, a process that appears to give some selectivity of action leading to improved activity [3].

References

Sensitivity of bone marrow hematopoietic colony-forming cells from mice, dogs, and humans to carminomycin, marcellomycin, aclacinomycin A, and N,N-dibenzyldaunorubicin and its relationship to clinical toxicity. Marsh, J.C., Brown, B.J., Nierenburg, M.M. Cancer Res. (1983) [Pubmed]
Adriamycin analogues. 3. Synthesis of N-alkylated anthracyclines with enhanced efficacy and reduced cardiotoxicity. Tong, G.L., Wu, H.Y., Smith, T.H., Henry, D.W. J. Med. Chem. (1979) [Pubmed]
Anthracycline mechanisms in analogue selection. Acton, E.M. Drugs under experimental and clinical research. (1985) [Pubmed]

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