Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN1061827 [(4S,5R)-4-hydroxy-5- (hydroxymethyl)oxolan...

Synonyms: CHEBI:28542, HMDB01351, AC1L971Z, 17210-42-3, deoxyribose-1-phosphate, ...

Pérez-Pérez, M.J. et al., Hotchkiss, K.A. et al.

Pérez-Pérez, Priego, Hernández, Camarasa, Balzarini, Liekens,

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High impact information on deoxyribose-1-phosphate

The chemotactic actions of TP plus thymidine were duplicated by the TP metabolite, 2-deoxyribose-1-phosphate (dR-1-P), and 10-fold more potently by its subsequent metabolite, 2-deoxyribose (2dR) [1].
Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties [2].

References

Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration. Hotchkiss, K.A., Ashton, A.W., Klein, R.S., Lenzi, M.L., Zhu, G.H., Schwartz, E.L. Cancer Res. (2003) [Pubmed]
Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications. Pérez-Pérez, M.J., Priego, E.M., Hernández, A.I., Camarasa, M.J., Balzarini, J., Liekens, S. Mini reviews in medicinal chemistry. (2005) [Pubmed]

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