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Chemical Compound Review

DEOXYRIBOSE     3,4,5-trihydroxypentanal

Synonyms: Thyminose, ACMC-209l6h, NSC-76307, AC1L1VXW, NSC76307, ...
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Disease relevance of DEOXYRIBOSE


High impact information on DEOXYRIBOSE


Chemical compound and disease context of DEOXYRIBOSE

  • The different kinetic properties toward AZT-MP between the eukaryotic TmpKs and E. coli TmpK can be rationalized by the different ways in which these enzymes stabilize the presumed transition state and the different manner in which a carboxylic acid side chain in the P loop interacts with the deoxyribose of the monophosphate [2].
  • Escherichia coli contains multiple enzymes that hydrolyze deoxyribose fragments (phosphoglycolaldehyde, PGA) from the 3' termini of a synthetic DNA substrate [11].
  • Escherichia coli [formamidopyrimidine]DNA glycosylase catalyses the nicking of both the phosphodiester bonds 3' and 5' of apurinic or apyrimidinic sites in DNA so that the base-free deoxyribose is replaced by a gap limited by 3'-phosphate and 5'-phosphate ends [12].
  • This compound is a guanosine analogue containing a 2',3'-unsaturation in its planar carbocyclic deoxyribose ring that acts on HIV-1 reverse transcriptase (RT(WT)) as a molecular target, resulting in chain termination of DNA synthesis [13].
  • Taken together with previous results showing hypersensitivity of A-T cells to ionizing radiation, bleomycin and neocarzinostatin, these data indicate that the critical DNA lesion in A-T cells is a strand break caused by deoxyribose destruction following the action of free radicals targeted into the DNA [14].

Biological context of DEOXYRIBOSE


Anatomical context of DEOXYRIBOSE


Associations of DEOXYRIBOSE with other chemical compounds


Gene context of DEOXYRIBOSE


Analytical, diagnostic and therapeutic context of DEOXYRIBOSE

  • Evidence for .OH generation was then sought using two different spin-trapping agents (5.5 dimethyl-pyrroline-1-oxide or N-t-butyl-alpha-phenylnitrone), as well as the deoxyribose oxidation assay [34].
  • AP sites are corrected via incision by AP endonucleases, removal of deoxyribose 5-phosphate, repair synthesis, and ligation [35].
  • Partial depurination of d-ApA produced two UV260nm-absorbing isomers, d-SpA and d-ApS (where S represents the depurinated deoxyribose sugar), that provided simple model compounds with which to examine, by HPLC, the response of nucleases to phosphodiester bonds flanked 3' or 5' by an apurinic site [36].
  • Bleomycin is an antibiotic used in cancer chemotherapy for its ability to achieve both single- and double-strand cleavage of DNA through abstraction of the deoxyribose C4'-H [37].
  • By contrast, a deoxyribose G5 variant that can undergo only the first of the two folding transitions gives a complex titration curve [38].


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  15. Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia. Frischer, H., Kennedy, E.J., Chigurupati, R., Sivarajan, M. J. Clin. Invest. (1993) [Pubmed]
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  19. Preferential hydroxylation by the chemical nuclease meso-tetrakis-(4-N-methylpyridiniumyl)porphyrinatomanganeseIII pentaacetate/KHSO5 at the 5' carbon of deoxyriboses on both 3' sides of three contiguous A.T base pairs in short double-stranded oligonucleotides. Pitié, M., Pratviel, G., Bernadou, J., Meunier, B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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