Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-G-88913 (2S)-2-[2-[3-[[4- [[[(2R,3S,4R,5R)-5-(6...

Synonyms: HMDB01269, CTK5D7422, AC1L972B, 73173-91-8, CH3-malonyl-CoA, ...

Dimroth, P. et al., Hoffmann, A. et al.

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Disease relevance of C00683

A prominent example is Propionigenium modestum, which converts the free energy of the decarboxylation of (S)-methylmalonyl-CoA to propionyl-CoA (DeltaG degrees =-20.6 kJ/mol) into an electrochemical Na(+) ion gradient across the membrane [1].
The steric course of the decarboxylation of (S)-methylmalonyl-CoA to propionyl-CoA, catalyzed by the biotin-dependent sodium pump methylmalonyl-CoA decarboxylase of Veillonella alcalescens was determined [2].

References

Bacterial Na+ - or H+ -coupled ATP synthases operating at low electrochemical potential. Dimroth, P., Cook, G.M. Adv. Microb. Physiol. (2004) [Pubmed]
Stereochemistry of the methylmalonyl-CoA decarboxylation reaction. Hoffmann, A., Dimroth, P. FEBS Lett. (1987) [Pubmed]

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