Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEBI:16181 (1S,2R,4S,5R)-6- aminocyclohexane-1,2,3,4,5...

Synonyms: AC1L97CT, C01214, C17578, neo-Inosamine-2, scyllo-Inosamine, ...

Rao, J.P. et al., Bahar, M. et al., Saint, C.P. et al.

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Disease relevance of C01214

We report the isolation and study of genes for the synthesis and catabolism of a new rhizopine, scyllo-inosamine (sIa), from alfalfa nodules induced by Rhizobium meliloti Rm220-3 [1].

High impact information on C01214

We propose a rhizopine catabolic model whereby MocB transports rhizopine into the cell and MocDE and MocF (or a similar protein elsewhere in the genome), under the regulation of MocR, act in concert to form a ferredoxin oxygenase system that demethylates 3-O-MSI to form scyllo-inosamine (SI) [2].
Rhizobium meliloti lacking mosA synthesizes the rhizopine scyllo-inosamine in place of 3-O-methyl-scyllo-inosamine [3].
The Rhizobium meliloti Rm220-3 mos locus producing the rhizopine scyllo-inosamine (SI) in nodules is shown to consist of three ORFs (ORF1, mosB and mosC) arranged in an operon structure [3].

References

Characterization of genes for synthesis and catabolism of a new rhizopine induced in nodules by Rhizobium meliloti Rm220-3: extension of the rhizopine concept. Saint, C.P., Wexler, M., Murphy, P.J., Tempé, J., Tate, M.E., Murphy, P.J. J. Bacteriol. (1993) [Pubmed]
A model for the catabolism of rhizopine in Rhizobium leguminosarum involves a ferredoxin oxygenase complex and the inositol degradative pathway. Bahar, M., de Majnik, J., Wexler, M., Fry, J., Poole, P.S., Murphy, P.J. Mol. Plant Microbe Interact. (1998) [Pubmed]
Rhizobium meliloti lacking mosA synthesizes the rhizopine scyllo-inosamine in place of 3-O-methyl-scyllo-inosamine. Rao, J.P., Grzemski, W., Murphy, P.J. Microbiology (Reading, Engl.) (1995) [Pubmed]

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