Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Pimaradiene (4aS,4bR,7S,10aS)-7-ethenyl- 1,1,4a,7...

Synonyms: CHEBI:8210, AC1L9A61, C06086, Sandaracopimaradiene, Pimara-8(14),15-diene, ...

Kang, H.S. et al., Ravn, M.M. et al.

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High impact information on Pimaradiene

In the second site, a putative tricyclic pimaradiene or pimarenyl(+) carbocation intermediate of undefined C13 stereochemistry and annular double bond position is formed [1].
Our previous study demonstrated that acanthoic acid, (-)-pimara-9(11), 15-dien-19-oic acid, a pimaradiene diterpene isolated from Acanthopanax koreanum, inhibited TNF-alpha production [2].

References

Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates. Ravn, M.M., Peters, R.J., Coates, R.M., Croteau, R. J. Am. Chem. Soc. (2002) [Pubmed]
Effects of acanthoic acid on TNF-alpha gene expression and haptoglobin synthesis. Kang, H.S., Song, H.K., Lee, J.J., Pyun, K.H., Choi, I. Mediators of inflammation. (1998) [Pubmed]

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