Disease relevance of Acanthopanax

• Effect of aqueous extracts of Acanthopanax senticosus on parathion toxicity in mice [1].
• The aim of this study was to determine whether Acanthopanax senticosus Harms (ASH) offers protection against Parkinson's disease (PD) and its related depressive behaviors in rats administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) [2].
• Protective effect of Acanthopanax senticosus against ethanol-induced apoptosis of human neuroblastoma cell line SK-N-MC [3].
• The hepatoprotective effects of Acanthopanax koreanum Nakai (Araliaceae) were evaluated in D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mouse [4].

High impact information on Acanthopanax

• Inhibition of prostaglandin E(2) production by taiwanin C isolated from the root of Acanthopanax chiisanensis and the mechanism of action [5].
• Six triterpenoids, chiisanogenin, chiisanoside, ursolic acid, oleanolic acid, beta-sitosterol and daucosterol, were isolated as the platelet anti-aggregating components from the leaves of Acanthopanax senticosus and the fruits of A. sessiliflorus [6].
• In vivo anti-inflammatory and antinociceptive effects of liriodendrin isolated from the stem bark of Acanthopanax senticosus [7].
• In the present study, liriodendrin isolated by activity-guided fractionation from the ethyl acetate (EtOAc) extracts of the stem bark of Acanthopanax senticosus, was evaluated for anti-inflammatory and antinociceptive activities [7].
• A new nitrogenous compound, named sessiline [5-(5-oxo-pyrrolidin-2-yloxymethyl)-furan-2-carbaldehyde (1)], was isolated from the fruits of Acanthopanax sessiliflorus, together with (-)-sesamin, scoparone, protocatechuic acid, ursolic acid, hyperin and 5-hydroxymethylfurfural by CC [8].

Chemical compound and disease context of Acanthopanax

• The aim of this study was to determine whether sesamin, a component from Acanthopanax senticosus HARMS (ASH) pharmacologically offers protection against Parkinson's disease (PD) and its related depressive behavior in rats administered rotenone [9].

Biological context of Acanthopanax

• Pretreatment of rats with Acanthopanax Radix extract administered orally for 30 days reduced the NO and lipid peroxidation levels, increased the activities of catalase and GSH-Px, and attenuated the renal dysfunction [10].

Anatomical context of Acanthopanax

• In rat peritoneal mast cells induced by anti-immunoglobulin E, ciwujianosides D1 (1) and C1 (2) from Acanthopanax senticosus (ciwujia) strongly inhibited histamine release in a concentration-dependent manner [11].
• Characterization of B cell membrane receptors of polysaccharide isolated from the root of Acanthopanax koreanum [12].
• The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited the significant inhibition of TPA-induced prostaglandin E(2) (PGE(2)) production in rat peritoneal macrophages [13].

Associations of Acanthopanax with chemical compounds

• Immunomodulatory activity of polysaccharide from Acanthopanax obovatus roots [14].
• Acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, is a pimaradiene diterpene isolated from the Korean medicinal plant, Acanthopanax koreanum [15].
• Analysis of flavonoid constituents from leaves of Acanthopanax senticosus harms by electrospray tandem mass spectrometry [16].
• The effects of the Acanthopanax obovatus polysaccharide (AOPS) as well as its combination with cyclophosphamide (CY) or prednisolone on immune responses were investigated in mice [14].
• Triterpenoid saponins of Acanthopanax nipponicus leaves [17].

Gene context of Acanthopanax

• Our previous study demonstrated that acanthoic acid, (-)-pimara-9(11), 15-dien-19-oic acid, a pimaradiene diterpene isolated from Acanthopanax koreanum, inhibited TNF-alpha production [18].
• Effect of Acanthopanax koreanum Nakai (Araliaceae) on D-galactosamine and lipopolysaccharide-induced fulminant hepatitis [4].
• Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum [19].
• Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase [20].
• Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum [21].

Analytical, diagnostic and therapeutic context of Acanthopanax

• We investigated the mechanism of the immunomodulatory action of polysaccharide (ASP) isolated from a cell culture of Acanthopanax senticosus [22].
• Quantitative determination of eleutheroside B and E from Acanthopanax species by high performance liquid chromatography [23].

References