Gene Review:
TNF - tumor necrosis factor
Homo sapiens
Synonyms:
Cachectin, DIF, TNF-a, TNF-alpha, TNFA, ...
Hornung,
Botchkina,
Wiener,
Daniel F. Battafarano,
P. Plomgaard,
A. M. W. Petersen,
Andrew B. Lemmey,
Malinin,
B. Lindegaard,
Gayatri Mittal,
Furuta,
Wang,
Siegel,
Ivanova,
Ikuma,
Goltsev,
Eaton,
Kovalenko,
C.P. Fischer,
Taishi,
Ian A. Clark,
Borovikova,
Collins,
Fang,
M. Penkowa,
Hishida,
Wang,
C. Broholm,
Wallach,
Ishizaki,
C. Erikstrup,
Korchak,
Angelique N. Collamer,
Perry,
Shirai,
Abumrad,
R. Krogh-Madsen,
S. Taudorf,
B.K. Pedersen,
Maini,
Peter J. Maddison,
O.H. Mortensen,
Yang,
Kubota,
Taane G. Clark,
Mahamadou Diakite,
Sarah Auburn,
Susana Campino,
Andrew E. Fry,
Angela Green,
Anna Richardson,
Kerrin Small,
Yik Y. Teo,
Jonathan Wilson,
Muminatou Jallow,
Fatou Sisay-Joof,
Margaret Pinder,
Michael J. Griffiths,
Norbert Peshu,
Thomas N. Williams,
Kevin Marsh,
Malcolm E. Molyneux,
Terrie E. Taylor,
Kirk A. Rockett,
Dominic P. Kwiatkowski,
Tracey,
Chan,
Karen T. Guerrero,
Obál,
Zheng,
Samuele M. Marcora,
Go,
Boldin,
Watkins,
Lenardo,
Acton,
Kathryn R. Chester,
Sun,
Juan F. Navarro,
Varfolomeev,
Feldmann,
Ware,
Kilpatrick,
Carmen Mora-Fernández,
A.R. Nielsen,
Zhang,
Sugimoto,
Jeffery S. Henning,
McFarland,
Krueger,
Ioannis Pandis,
- Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. Keffer, J., Probert, L., Cazlaris, H., Georgopoulos, S., Kaslaris, E., Kioussis, D., Kollias, G. EMBO. J. (1991)
- CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Smith, C.A., Gruss, H.J., Davis, T., Anderson, D., Farrah, T., Baker, E., Sutherland, G.R., Brannan, C.I., Copeland, N.G., Jenkins, N.A. Cell (1993)
- Human TNF mutants with selective activity on the p55 receptor. Van Ostade, X., Vandenabeele, P., Everaerdt, B., Loetscher, H., Gentz, R., Brockhaus, M., Lesslauer, W., Tavernier, J., Brouckaert, P., Fiers, W. Nature (1993)
- Membrane tumor necrosis factor (TNF) induced cooperative signaling of TNFR60 and TNFR80 favors induction of cell death rather than virus production in HIV-infected T cells. Lazdins, J.K., Grell, M., Walker, M.R., Woods-Cook, K., Scheurich, P., Pfizenmaier, K. J. Exp. Med. (1997)
- T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. Miethke, T., Wahl, C., Heeg, K., Echtenacher, B., Krammer, P.H., Wagner, H. J. Exp. Med. (1992)
- The role of TNF-alpha in diabetic nephropathy: pathogenic and therapeutic implications. Navarro, J.F., Mora-Fernández, C. Cytokine Growth Factor Rev. (2006)
- Randomized phase 2 trial of anti-tumor necrosis factor therapy for cachexia in patients with early rheumatoid arthritis. Marcora, S.M., Chester, K.R., Mittal, G., Lemmey, A.B., Maddison, P.J. Am. J. Clin. Nutr. (2006)
- How TNF was recognized as a key mechanism of disease. Clark, I.A. Cytokine Growth Factor Rev. (2007)
- Psoriatic skin lesions induced by tumor necrosis factor antagonist therapy: a literature review and potential mechanisms of action. Collamer, A.N., Guerrero, K.T., Henning, J.S., Battafarano, D.F. Arthritis Rheum. (2008)
- Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Bruunsgaard, H., Andersen-Ranberg, K., Hjelmborg, J.B., Pedersen, B.K., Jeune, B. Am. J. Med. (2003)
- Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy. Sugimoto, M., Furuta, T., Shirai, N., Ikuma, M., Hishida, A., Ishizaki, T. Clin. Pharmacol. Ther. (2006)
- The role of TNF and its receptors in Alzheimer's disease. Perry, R.T., Collins, J.S., Wiener, H., Acton, R., Go, R.C. Neurobiol. Aging (2001)
- Influence of pentoxifylline on cytokine levels and inflammatory parameters in septic shock. Staudinger, T., Presterl, E., Graninger, W., Locker, G.J., Knapp, S., Laczika, K., Klappacher, G., Stoiser, B., Wagner, A., Tesinsky, P., Kordova, H., Frass, M. Intensive care medicine. (1996)
- The role of cytokines in physiological sleep regulation. Krueger, J.M., Obál, F.J., Fang, J., Kubota, T., Taishi, P. Ann. N. Y. Acad. Sci. (2001)
- Network communications: lymphotoxins, LIGHT, and TNF. Ware, C.F. Annu. Rev. Immunol. (2005)
- Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Feldmann, M., Maini, R.N. Annu. Rev. Immunol. (2001)
- Tumor necrosis factor receptor and Fas signaling mechanisms. Wallach, D., Varfolomeev, E.E., Malinin, N.L., Goltsev, Y.V., Kovalenko, A.V., Boldin, M.P. Annu. Rev. Immunol. (1999)
- Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. Lenardo, M., Chan, K.M., Hornung, F., McFarland, H., Siegel, R., Wang, J., Zheng, L. Annu. Rev. Immunol. (1999)
- Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure. VEST Investigators for TNF Genotype Analysis. Vesnarinone Survival Trial. Kubota, T., McNamara, D.M., Wang, J.J., Trost, M., McTiernan, C.F., Mann, D.L., Feldman, A.M. Circulation (1998)
- Retinoids downregulate both p60 and p80 forms of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells. Totpal, K., Chaturvedi, M.M., LaPushin, R., Aggarwal, B.B. Blood (1995)
- Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Liedtke, C., Plümpe, J., Kubicka, S., Bradham, C.A., Manns, M.P., Brenner, D.A., Trautwein, C. Hepatology (2002)
- Cytokine levels and systemic toxicity in patients undergoing isolated limb perfusion with high-dose tumor necrosis factor, interferon gamma, and melphalan. Thom, A.K., Alexander, H.R., Andrich, M.P., Barker, W.C., Rosenberg, S.A., Fraker, D.L. J. Clin. Oncol. (1995)
- Resistance to TNF-alpha and adriamycin in the human breast cancer MCF-7 cell line: relationship to MDR1, MnSOD, and TNF gene expression. Zyad, A., Bénard, J., Tursz, T., Clarke, R., Chouaib, S. Cancer Res. (1994)
- Associations between insulin resistance and TNF-alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes. Plomgaard, P., Nielsen, A.R., Fischer, C.P., Mortensen, O.H., Broholm, C., Penkowa, M., Krogh-Madsen, R., Erikstrup, C., Lindegaard, B., Petersen, A.M., Taudorf, S., Pedersen, B.K. Diabetologia (2007)
- Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Liu, Z.G., Hsu, H., Goeddel, D.V., Karin, M. Cell (1996)
- The response of human epithelial cells to TNF involves an inducible autocrine cascade. Janes, K.A., Gaudet, S., Albeck, J.G., Nielsen, U.B., Lauffenburger, D.A., Sorger, P.K. Cell (2006)
- A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Park, Y.C., Ye, H., Hsia, C., Segal, D., Rich, R.L., Liou, H.C., Myszka, D.G., Wu, H. Cell (2000)
- Molecular cloning and expression of a receptor for human tumor necrosis factor. Schall, T.J., Lewis, M., Koller, K.J., Lee, A., Rice, G.C., Wong, G.H., Gatanaga, T., Granger, G.A., Lentz, R., Raab, H. Cell (1990)
- The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Grell, M., Douni, E., Wajant, H., Löhden, M., Clauss, M., Maxeiner, B., Georgopoulos, S., Lesslauer, W., Kollias, G., Pfizenmaier, K., Scheurich, P. Cell (1995)
- Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Erickson, S.L., de Sauvage, F.J., Kikly, K., Carver-Moore, K., Pitts-Meek, S., Gillett, N., Sheehan, K.C., Schreiber, R.D., Goeddel, D.V., Moore, M.W. Nature (1994)
- Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon. Aggarwal, B.B., Eessalu, T.E., Hass, P.E. Nature (1985)
- Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Borovikova, L.V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G.I., Watkins, L.R., Wang, H., Abumrad, N., Eaton, J.W., Tracey, K.J. Nature (2000)
- TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Chen, G., Cao, P., Goeddel, D.V. Mol. Cell (2002)
- A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon. Welborn, M.B., Van Zee, K., Edwards, P.D., Pruitt, J.H., Kaibara, A., Vauthey, J.N., Rogy, M., Castleman, W.L., Lowry, S.F., Kenney, J.S., Stüber, D., Ettlin, U., Wipf, B., Loetscher, H., Copeland, E.M., Lesslauer, W., Moldawer, L.L. J. Exp. Med. (1996)
- Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. Haimovitz-Friedman, A., Kan, C.C., Ehleiter, D., Persaud, R.S., McLoughlin, M., Fuks, Z., Kolesnick, R.N. J. Exp. Med. (1994)
- Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. Martich, G.D., Danner, R.L., Ceska, M., Suffredini, A.F. J. Exp. Med. (1991)
- Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I. Hildt, E., Oess, S. J. Exp. Med. (1999)
- Interleukin 18 stimulates HIV type 1 in monocytic cells. Shapiro, L., Puren, A.J., Barton, H.A., Novick, D., Peskind, R.L., Shenkar, R., Gu, Y., Su, M.S., Dinarello, C.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity. Muñoz, C., Pascual-Salcedo, D., Castellanos, M.C., Alfranca, A., Aragonés, J., Vara, A., Redondo, J.M., de Landázuri, M.O. Blood (1996)
- Differential effects of gangliosides on Ig production and proliferation by human B cells. Kimata, H., Yoshida, A. Blood (1994)
- TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. Leo, E., Deveraux, Q.L., Buchholtz, C., Welsh, K., Matsuzawa, S., Stennicke, H.R., Salvesen, G.S., Reed, J.C. J. Biol. Chem. (2001)
- Contribution of TNF-alpha converting enzyme and proteinase-3 to TNF-alpha processing in human alveolar macrophages. Armstrong, L., Godinho, S.I., Uppington, K.M., Whittington, H.A., Millar, A.B. Am. J. Respir. Cell Mol. Biol. (2006)
- Selective regulation by delta-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils. Kilpatrick, L.E., Sun, S., Korchak, H.M. Am. J. Physiol., Cell Physiol. (2004)
- Tumor necrosis factor-alpha induced the release of interleukin-6 from endometriotic stromal cells by the nuclear factor-kappaB and mitogen-activated protein kinase pathways. Yamauchi, N., Harada, T., Taniguchi, F., Yoshida, S., Iwabe, T., Terakawa, N. Fertil. Steril. (2004)
- Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression. Huang, W.C., Chen, J.J., Inoue, H., Chen, C.C. J. Immunol. (2003)
- Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Döcke, W.D., Randow, F., Syrbe, U., Krausch, D., Asadullah, K., Reinke, P., Volk, H.D., Kox, W. Nat. Med. (1997)
- Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. McInnes, I.B., Leung, B.P., Sturrock, R.D., Field, M., Liew, F.Y. Nat. Med. (1997)
- Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees. van der Poll, T., Jansen, J., Levi, M., ten Cate, H., ten Cate, J.W., van Deventer, S.J. J. Exp. Med. (1994)
- Regulation of cytokine production by soluble CD23: costimulation of interferon gamma secretion and triggering of tumor necrosis factor alpha release. Armant, M., Ishihara, H., Rubio, M., Delespesse, G., Sarfati, M. J. Exp. Med. (1994)
- Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55. Mackay, F., Loetscher, H., Stueber, D., Gehr, G., Lesslauer, W. J. Exp. Med. (1993)
- Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells. Rossol, M., Meusch, U., Pierer, M., Kaltenhäuser, S., Häntzschel, H., Hauschildt, S., Wagner, U. J. Immunol. (2007)
- Smad7 sensitizes tumor necrosis factor induced apoptosis through the inhibition of antiapoptotic gene expression by suppressing activation of the nuclear factor-kappaB pathway. Hong, S., Lee, C., Kim, S.J. Cancer Res. (2007)
- Distinctive role of integrin-mediated adhesion in TNF-induced PKB/Akt and NF-kappaB activation and endothelial cell survival. Bieler, G., Hasmim, M., Monnier, Y., Imaizumi, N., Ameyar, M., Bamat, J., Ponsonnet, L., Chouaib, S., Grell, M., Goodman, S.L., Lejeune, F., Rüegg, C. Oncogene (2007)
- Epstein-Barr virus (EBV) latent membrane protein-1 down-regulates tumor necrosis factor-alpha (TNF-alpha) receptor-1 and confers resistance to TNF-alpha-induced apoptosis in T cells: implication for the progression to T-cell lymphoma in EBV-associated hemophagocytic syndrome. Chuang, H.C., Lay, J.D., Chuang, S.E., Hsieh, W.C., Chang, Y., Su, I.J. Am. J. Pathol. (2007)
- HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Rushworth, S.A., MacEwan, D.J. Blood (2008)
- Role of cytokines in rheumatoid arthritis. Feldmann, M., Brennan, F.M., Maini, R.N. Annu. Rev. Immunol. (1996)
- Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Browning, J.L., Ngam-ek, A., Lawton, P., DeMarinis, J., Tizard, R., Chow, E.P., Hession, C., O'Brine-Greco, B., Foley, S.F., Ware, C.F. Cell (1993)
- TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Li, X., Yang, Y., Ashwell, J.D. Nature (2002)
- TNF-alpha (-308 G/A) and CD14 (-159T/C) polymorphisms in the bronchial responsiveness of Korean children with asthma. Hong, S.J., Kim, H.B., Kang, M.J., Lee, S.Y., Kim, J.H., Kim, B.S., Jang, S.O., Shin, H.D., Park, C.S. J. Allergy Clin. Immunol. (2007)
- CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation. Liao, W., Xiao, Q., Tchikov, V., Fujita, K., Yang, W., Wincovitch, S., Garfield, S., Conze, D., El-Deiry, W.S., Schütze, S., Srinivasula, S.M. Curr. Biol. (2008)
- Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. Clark, T.G., Diakite, M., Auburn, S., Campino, S., Fry, A.E., Green, A., Richardson, A., Small, K., Teo, Y.Y., Wilson, J., Jallow, M., Sisay-Joof, F., Pinder, M., Griffiths, M.J., Peshu, N., Williams, T.N., Marsh, K., Molyneux, M.E., Taylor, T.E., Rockett, K.A., Kwiatkowski, D.P. J. Infect. Dis. (2009)
- Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by phorbol myristate acetate and anti-CD3 antibody. Sung, S.S., Bjorndahl, J.M., Wang, C.Y., Kao, H.T., Fu, S.M. J. Exp. Med. (1988)