Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Heliotridine (1S,8S)-7-(hydroxymethyl)- 2,3,5,8...

Synonyms: AC1L9DBH, AKOS006279573, C10321, 520-63-8

Hartmann, T. et al., Xia, Q. et al., Hammouda, F.M. et al.

Hartmann, Theuring, Witte, Schulz, Pasteels,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on C10321

In this study, we report that metabolism of lasiocarpine, the prototype heliotridine PA, by F344 rat liver microsomes resulted in the formation of DHP [1].
Using P. boucardi as subject, three mechanisms were studied: (i). utilization of host plant alkaloids that are not sequestered per se; (ii). elucidation of the mechanism of the already documented C-7 epimerization of heliotridine O(9)-monoesters; (iii). the specificity of insect catalyzed necine base esterification [2].

Analytical, diagnostic and therapeutic context of C10321

Moreover, HPLC and GLC showed the probable presence of heliotridine and some other unidentified minor constituents [3].

References

Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine. Xia, Q., Chou, M.W., Edgar, J.A., Doerge, D.R., Fu, P.P. Cancer Lett. (2006) [Pubmed]
Biochemical processing of plant acquired pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi. Hartmann, T., Theuring, C., Witte, L., Schulz, S., Pasteels, J.M. Insect Biochem. Mol. Biol. (2003) [Pubmed]
Poisonous plants contaminating edible ones and toxic substances in plant foods. Part 3. Pyrrolizidine alkaloids from Heliotropium digynum Forssk. (= H. luteum, Poir.). Hammouda, F.M., Rizk, A.M., Ismail, S.I., Atteya, S.Z., Ghaleb, H.A., Madkour, M.K., Pohland, A.E., Wood, G. Die Pharmazie. (1984) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share