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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Heliotridine     (1S,8S)-7-(hydroxymethyl)- 2,3,5,8...

Synonyms: AC1L9DBH, AKOS006279573, C10321, 520-63-8
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High impact information on C10321

  • In this study, we report that metabolism of lasiocarpine, the prototype heliotridine PA, by F344 rat liver microsomes resulted in the formation of DHP [1].
  • Using P. boucardi as subject, three mechanisms were studied: (i). utilization of host plant alkaloids that are not sequestered per se; (ii). elucidation of the mechanism of the already documented C-7 epimerization of heliotridine O(9)-monoesters; (iii). the specificity of insect catalyzed necine base esterification [2].

Analytical, diagnostic and therapeutic context of C10321

  • Moreover, HPLC and GLC showed the probable presence of heliotridine and some other unidentified minor constituents [3].


  1. Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine. Xia, Q., Chou, M.W., Edgar, J.A., Doerge, D.R., Fu, P.P. Cancer Lett. (2006) [Pubmed]
  2. Biochemical processing of plant acquired pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi. Hartmann, T., Theuring, C., Witte, L., Schulz, S., Pasteels, J.M. Insect Biochem. Mol. Biol. (2003) [Pubmed]
  3. Poisonous plants contaminating edible ones and toxic substances in plant foods. Part 3. Pyrrolizidine alkaloids from Heliotropium digynum Forssk. (= H. luteum, Poir.). Hammouda, F.M., Rizk, A.M., Ismail, S.I., Atteya, S.Z., Ghaleb, H.A., Madkour, M.K., Pohland, A.E., Wood, G. Die Pharmazie. (1984) [Pubmed]
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