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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Microsomes, Liver

 
 
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Disease relevance of Microsomes, Liver

 

Psychiatry related information on Microsomes, Liver

 

High impact information on Microsomes, Liver

 

Chemical compound and disease context of Microsomes, Liver

 

Biological context of Microsomes, Liver

 

Anatomical context of Microsomes, Liver

  • However, the activities of UDPglucuronyltransferases and most forms of glutathione S-transferase did not change significantly with increasing age in liver microsomes and cytosol, respectively [23].
  • The affinities for bilirubin of B-UGT1 expressed in COS cells and B-UGT from human liver microsomes were similar with Km of 5.1 +/- 0.9 microM and 7.9 +/- 5.3 microM, respectively [24].
  • This hypothesis is strongly supported by the demonstration that thapsigargin causes a rapid inhibition of the Ca2(+)-activated ATPase activity of rat liver microsomes, with an identical dose dependence to that seen in whole cell or isolated microsome Ca2+ discharge [25].
  • Sterigmatocystin (ST), a potent hepatocarcinogen, was covalently bound to calf thymus DNA by incubation in the presence of phenobarbital-induced rat liver microsomes [26].
  • The toxic metabolite of thalidomide was not produced by rat liver microsomes (the rat is not sensitive to thalidomide teratogenesis) but was produced by hepatic preparations from maternal rabbits, and rabbit, monkey, and human (all sensitive species) fetuses [27].
 

Associations of Microsomes, Liver with chemical compounds

 

Gene context of Microsomes, Liver

  • CYP3A7, a form found prominently in human fetal liver microsomes, was first isolated as a liver 16-alpha-dehydroepiandrosterone-sulfate hydroxylase [33].
  • Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes [34].
  • Experiments with P-450 form-selective chemical inhibitors and inhibitory anti-P-450 antibodies were then performed to determine the contributions of individual P-450s to the activation of these drugs in human liver microsomes [34].
  • Reactions catalyzed by purified P-450MP-1 and P-450MP-2 preparations and inhibited by anti-P-450MP in human liver microsomes include S-mephenytoin 4-hydroxylation, S-nirvanol 4-hydroxylation, S-mephenytoin N-demethylation, and diphenylhydantoin 4-hydroxylation [35].
  • Overall, iNOS activity is distinctly different from the major cytochrome P-450 enzymes in human liver microsomes [36].
 

Analytical, diagnostic and therapeutic context of Microsomes, Liver

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  28. Rabbit hepatic progesterone 21-hydroxylase exhibits a bimodal distribution of activity. Dieter, H.H., Muller-Eberhard, U., Johnson, E.F. Science (1982) [Pubmed]
  29. Prelytic damage of red cells in filtrates from peroxidizing microsomes. Roders, M.K., Glende, E.A., Recknagel, R.O. Science (1977) [Pubmed]
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