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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Microsomes, Liver

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Disease relevance of Microsomes, Liver


Psychiatry related information on Microsomes, Liver


High impact information on Microsomes, Liver


Chemical compound and disease context of Microsomes, Liver


Biological context of Microsomes, Liver


Anatomical context of Microsomes, Liver

  • However, the activities of UDPglucuronyltransferases and most forms of glutathione S-transferase did not change significantly with increasing age in liver microsomes and cytosol, respectively [23].
  • The affinities for bilirubin of B-UGT1 expressed in COS cells and B-UGT from human liver microsomes were similar with Km of 5.1 +/- 0.9 microM and 7.9 +/- 5.3 microM, respectively [24].
  • This hypothesis is strongly supported by the demonstration that thapsigargin causes a rapid inhibition of the Ca2(+)-activated ATPase activity of rat liver microsomes, with an identical dose dependence to that seen in whole cell or isolated microsome Ca2+ discharge [25].
  • Sterigmatocystin (ST), a potent hepatocarcinogen, was covalently bound to calf thymus DNA by incubation in the presence of phenobarbital-induced rat liver microsomes [26].
  • The toxic metabolite of thalidomide was not produced by rat liver microsomes (the rat is not sensitive to thalidomide teratogenesis) but was produced by hepatic preparations from maternal rabbits, and rabbit, monkey, and human (all sensitive species) fetuses [27].

Associations of Microsomes, Liver with chemical compounds


Gene context of Microsomes, Liver

  • CYP3A7, a form found prominently in human fetal liver microsomes, was first isolated as a liver 16-alpha-dehydroepiandrosterone-sulfate hydroxylase [33].
  • Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes [34].
  • Experiments with P-450 form-selective chemical inhibitors and inhibitory anti-P-450 antibodies were then performed to determine the contributions of individual P-450s to the activation of these drugs in human liver microsomes [34].
  • Reactions catalyzed by purified P-450MP-1 and P-450MP-2 preparations and inhibited by anti-P-450MP in human liver microsomes include S-mephenytoin 4-hydroxylation, S-nirvanol 4-hydroxylation, S-mephenytoin N-demethylation, and diphenylhydantoin 4-hydroxylation [35].
  • Overall, iNOS activity is distinctly different from the major cytochrome P-450 enzymes in human liver microsomes [36].

Analytical, diagnostic and therapeutic context of Microsomes, Liver


  1. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells. Smith, T.J., Guo, Z., Gonzalez, F.J., Guengerich, F.P., Stoner, G.D., Yang, C.S. Cancer Res. (1992) [Pubmed]
  2. Changes in fatty acid composition of plasma, liver microsomes, and erythrocytes in liver cirrhosis induced by oral intake of thioacetamide in rats. Moreira, E., Fontana, L., Periago, J.L., Sanchéz De Medina, F., Gil, A. Hepatology (1995) [Pubmed]
  3. Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivo. Manns, M., Zanger, U., Gerken, G., Sullivan, K.F., Meyer zum Büschenfelde, K.H., Meyer, U.A., Eichelbaum, M. Hepatology (1990) [Pubmed]
  4. Mechanism of melphalan resistance developed in vitro in human melanoma cells. Parsons, P.G., Carter, F.B., Morrison, L., Regius Mary Sister, n.u.l.l. Cancer Res. (1981) [Pubmed]
  5. Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4. Pillot, T., Ouzzine, M., Fournel-Gigleux, S., Lafaurie, C., Radominska, A., Burchell, B., Siest, G., Magdalou, J. J. Biol. Chem. (1993) [Pubmed]
  6. Effect of alcohol on lipoprotein metabolism. I. High density lipoprotein binding. Parkes, J.G., Hussain, R.A., Goldberg, D.M. Clinical physiology and biochemistry. (1989) [Pubmed]
  7. Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4. Taniguchi, R., Kumai, T., Matsumoto, N., Watanabe, M., Kamio, K., Suzuki, S., Kobayashi, S. J. Pharmacol. Sci. (2005) [Pubmed]
  8. Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter. Bishop, W.R., Bell, R.M. Cell (1985) [Pubmed]
  9. Odorant signal termination by olfactory UDP glucuronosyl transferase. Lazard, D., Zupko, K., Poria, Y., Nef, P., Lazarovits, J., Horn, S., Khen, M., Lancet, D. Nature (1991) [Pubmed]
  10. The possible functional significance of phosphatidylethanolamine methylation. Vance, D.E., de Kruijff, B. Nature (1980) [Pubmed]
  11. Rat liver microsomes catalyse covalent binding of 14C-vinyl chloride to macromolecules. Kappus, H., Bold, H.M., Buchter, A., Bolt, W. Nature (1975) [Pubmed]
  12. Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid. Rettie, A.E., Rettenmeier, A.W., Howald, W.N., Baillie, T.A. Science (1987) [Pubmed]
  13. Biochemical factors in alcoholic liver disease. Lieber, C.S. Semin. Liver Dis. (1993) [Pubmed]
  14. Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4. Bargetzi, M.J., Aoyama, T., Gonzalez, F.J., Meyer, U.A. Clin. Pharmacol. Ther. (1989) [Pubmed]
  15. Liver microsomal transport of glucose-6-phosphate, glucose, and phosphate in type 1 glycogen storage disease. Marcolongo, P., Bánhegyi, G., Benedetti, A., Hinds, C.J., Burchell, A. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  16. Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin. Eberhart, D.C., Gemzik, B., Halvorson, M.R., Parkinson, A. Mol. Pharmacol. (1991) [Pubmed]
  17. Mutagenicity testing of steroids obtained from bile acids and cholesterol. McKillop, C.A., Owen, R.W., Bilton, R.F., Haslam, E.A. Carcinogenesis (1983) [Pubmed]
  18. Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation. Dix, T.A., Marnett, L.J. Science (1983) [Pubmed]
  19. Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat. Rudling, M., Parini, P., Angelin, B. J. Clin. Invest. (1997) [Pubmed]
  20. Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes. Shefer, S., Salen, G., Batta, A.K., Honda, A., Tint, G.S., Irons, M., Elias, E.R., Chen, T.C., Holick, M.F. J. Clin. Invest. (1995) [Pubmed]
  21. Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II. Zanger, U.M., Hauri, H.P., Loeper, J., Homberg, J.C., Meyer, U.A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  22. Kinetics of carbon monoxide binding to phenobarbital-induced cytochrome P-450 from rat liver microsomes: a simple bimolecular process. Oertle, M., Richter, C., Winterhalter, K.H., Di Iorio, E.E. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  23. Metabolism, covalent binding, and mutagenicity of aflatoxin B1 by liver extracts from rats of various ages. Jayaraj, A., Hardwick, J.P., Diller, T.W., Richardson, A.G. J. Natl. Cancer Inst. (1985) [Pubmed]
  24. Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase. Seppen, J., Bosma, P.J., Goldhoorn, B.G., Bakker, C.T., Chowdhury, J.R., Chowdhury, N.R., Jansen, P.L., Oude Elferink, R.P. J. Clin. Invest. (1994) [Pubmed]
  25. Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. Thastrup, O., Cullen, P.J., Drøbak, B.K., Hanley, M.R., Dawson, A.P. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  26. Sterigmatocystin-DNA interactions: identification of a major adduct formed after metabolic activation in vitro. Essigmann, J.M., Barker, L.J., Fowler, K.W., Francisco, M.A., Reinhold, V.N., Wogan, G.N. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  27. Thalidomide teratogenesis: evidence for a toxic arene oxide metabolite. Gordon, G.B., Spielberg, S.P., Blake, D.A., Balasubramanian, V. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  28. Rabbit hepatic progesterone 21-hydroxylase exhibits a bimodal distribution of activity. Dieter, H.H., Muller-Eberhard, U., Johnson, E.F. Science (1982) [Pubmed]
  29. Prelytic damage of red cells in filtrates from peroxidizing microsomes. Roders, M.K., Glende, E.A., Recknagel, R.O. Science (1977) [Pubmed]
  30. Chemical evidence for production of hydroxyl radicals during microsomal electron transfer. Cohen, G., Cederbaum, A.I. Science (1979) [Pubmed]
  31. Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat. Nelson, S.D., Mitchell, J.R., Timbrell, J.A., Snodgrass, W.R., Corcoran, G.B. Science (1976) [Pubmed]
  32. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Saric, T., Chang, S.C., Hattori, A., York, I.A., Markant, S., Rock, K.L., Tsujimoto, M., Goldberg, A.L. Nat. Immunol. (2002) [Pubmed]
  33. Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta. Schuetz, J.D., Kauma, S., Guzelian, P.S. J. Clin. Invest. (1993) [Pubmed]
  34. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Chang, T.K., Weber, G.F., Crespi, C.L., Waxman, D.J. Cancer Res. (1993) [Pubmed]
  35. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. Shimada, T., Misono, K.S., Guengerich, F.P. J. Biol. Chem. (1986) [Pubmed]
  36. Characterization of inducible nitric-oxide synthase by cytochrome P-450 substrates and inhibitors. Inhibition by chlorzoxazone. Grant, S.K., Green, B.G., Wang, R., Pacholok, S.G., Kozarich, J.W. J. Biol. Chem. (1997) [Pubmed]
  37. Effects of administration to mice of butylated hydroxyanisole by oral intubation on benzo[a]pyrene-induced pulmonary adenoma formation and metabolism of benzo[a]pyrene. Speier, J.L., Lam, L.K., Wattenberg, L.W. J. Natl. Cancer Inst. (1978) [Pubmed]
  38. Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1. Manns, M.P., Johnson, E.F., Griffin, K.J., Tan, E.M., Sullivan, K.F. J. Clin. Invest. (1989) [Pubmed]
  39. Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids. Capdevila, J., Marnett, L.J., Chacos, N., Prough, R.A., Estabrook, R.W. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  40. Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LA omega) by dehydroepiandrosterone in rats: a possible peroxisomal proliferator. Wu, H.Q., Masset-Brown, J., Tweedie, D.J., Milewich, L., Frenkel, R.A., Martin-Wixtrom, C., Estabrook, R.W., Prough, R.A. Cancer Res. (1989) [Pubmed]
  41. Evidence for metabolic alpha hydroxylation of N-nitrosopyrrolidine. Hecht, S.S., Chen, C.B., Hoffmann, D. Cancer Res. (1978) [Pubmed]
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