Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Grandisin (2S,3S,4S,5S)-3,4-dimethyl- 2,5-bis(3,4,5...

Synonyms: ZINC04098808, AC1L9DK8, C10622, 53250-50-3

Greger, H. et al., Bernardes, L.S. et al.

Greger, Pacher, Vajrodaya, Bacher, Hofer,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Grandisin

The natural products veraguensin (1) and grandisin (2) have shown potent in vitro activity against trypomastigote parasite (Y strain) with IC(50) 2.3muM (1) and 3.7muM (2) [1].
Six new amides, leptaglin (1), hemileptaglin (2), aglanthin (3), agleptin (4), isoagleptin (5), and leptanthin (6), together with known lignans yangambin, eudesmin, grandisin (7), epigrandisin (8), and dehydrodiconiferyl alcohol, were isolated and identified from the lipophilic leaf and stem bark extracts of Aglaia leptantha [2].

References

Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol. Bernardes, L.S., Kato, M.J., Albuquerque, S., Carvalho, I. Bioorg. Med. Chem. (2006) [Pubmed]
Infraspecific variation of sulfur-containing bisamides from Aglaia leptantha. Greger, H., Pacher, T., Vajrodaya, S., Bacher, M., Hofer, O. J. Nat. Prod. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share