Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Eudesmin 4,8-bis(3,4-dimethoxyphenyl)- 3,7...

Synonyms: Eudesamin, AGN-PC-00HRRS, AG-K-26047, CBDivE_012962, NSC-35476, ...

Cho, J.Y. et al., Chae, S.H. et al.

Cho, Yoo, Baik, Park,

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High impact information on Eudesmin

Eudesmin inhibits tumor necrosis factor-alpha production and T cell proliferation [1].
Possible antiinflammatory effects of eudesmin were examined by assessing the effects on tumor necrosis factor (TNF)-alpha production and lymphocyte proliferation as well as cytotoxicity against murine and human macrophages [1].
All three lignans showed inhibitory effects on TNF-alpha production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50 = 51 microM) [2].

References

Eudesmin inhibits tumor necrosis factor-alpha production and T cell proliferation. Cho, J.Y., Yoo, E.S., Baik, K.U., Park, M.H. Arch. Pharm. Res. (1999) [Pubmed]
Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii. Chae, S.H., Kim, P.S., Cho, J.Y., Park, J.S., Lee, J.H., Yoo, E.S., Baik, K.U., Lee, J.S., Park, M.H. Arch. Pharm. Res. (1998) [Pubmed]

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