Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL6269 (2S)-6-amino-N-(2- cyclohexylethyl)-2...

Synonyms: CHEBI:100198, SC-58272, DNC004076, AC1L9JM6, SC 58272, ...

Zhang, L. et al., Lodge, J.K. et al.

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When compared with wild type Nmt1p, Cys217 --> Arg produces 3- and 6-fold increases in Ki for SC-58272 at 24 and 37 degrees C but no change in Ki for S-(2-oxo)pentadecyl-CoA, indicating that the substitution selectively affects Nmt1p's peptide binding site [1].
SC-58272, which is related to SC-59383, was a more potent inhibitor in vitro (IC50 0.056 +/- 0.01 microM), but had no growth inhibitory activity and did not produce any detectable reduction in Arf N-myristoylation [2].

References

Biochemical studies of Saccharomyces cerevisiae myristoyl-coenzyme A:protein N-myristoyltransferase mutants. Zhang, L., Jackson-Machelski, E., Gordon, J.I. J. Biol. Chem. (1996) [Pubmed]
N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase. Lodge, J.K., Jackson-Machelski, E., Devadas, B., Zupec, M.E., Getman, D.P., Kishore, N., Freeman, S.K., McWherter, C.A., Sikorski, J.A., Gordon, J.I. Microbiology (Reading, Engl.) (1997) [Pubmed]

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