Gene Review:
NMT1 - glycylpeptide N-tetradecanoyltransferase NMT1
Saccharomyces cerevisiae S288c
Synonyms:
CDC72, Cell division control protein 72, Glycylpeptide N-tetradecanoyltransferase, L8167.14, Myristoyl-CoA:protein N-myristoyltransferase, ...
- Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. Duronio, R.J., Jackson-Machelski, E., Heuckeroth, R.O., Olins, P.O., Devine, C.S., Yonemoto, W., Slice, L.W., Taylor, S.S., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1990)
- 4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. Langner, C.A., Lodge, J.K., Travis, S.J., Caldwell, J.E., Lu, T., Li, Q., Bryant, M.L., Devadas, B., Gokel, G.W., Kobayashi, G.S. J. Biol. Chem. (1992)
- Comparison of the acyl chain specificities of human myristoyl-CoA synthetase and human myristoyl-CoA:protein N-myristoyltransferase. Kishore, N.S., Wood, D.C., Mehta, P.P., Wade, A.C., Lu, T., Gokel, G.W., Gordon, J.I. J. Biol. Chem. (1993)
- The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Polar probes of the enzyme's myristoyl-CoA recognition site. Lu, T., Li, Q., Katoh, A., Hernandez, J., Duffin, K., Jackson-Machelski, E., Knoll, L.J., Gokel, G.W., Gordon, J.I. J. Biol. Chem. (1994)
- Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major. Panethymitaki, C., Bowyer, P.W., Price, H.P., Leatherbarrow, R.J., Brown, K.A., Smith, D.F. Biochem. J. (2006)
- Disruption of the yeast N-myristoyl transferase gene causes recessive lethality. Duronio, R.J., Towler, D.A., Heuckeroth, R.O., Gordon, J.I. Science (1989)
- N-myristoylation is required for function of the pheromone-responsive G alpha protein of yeast: conditional activation of the pheromone response by a temperature-sensitive N-myristoyl transferase. Stone, D.E., Cole, G.M., de Barros Lopes, M., Goebl, M., Reed, S.I. Genes Dev. (1991)
- Nascent transcription from the nmt1 and nmt2 genes of Schizosaccharomyces pombe overlaps neighbouring genes. Hansen, K., Birse, C.E., Proudfoot, N.J. EMBO J. (1998)
- Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism. Johnson, D.R., Knoll, L.J., Levin, D.E., Gordon, J.I. J. Cell Biol. (1994)
- Use of Escherichia coli strains containing fad mutations plus a triple plasmid expression system to study the import of myristate, its activation by Saccharomyces cerevisiae acyl-CoA synthetase, and its utilization by S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Knoll, L.J., Gordon, J.I. J. Biol. Chem. (1993)
- Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy. Johnson, D.R., Duronio, R.J., Langner, C.A., Rudnick, D.A., Gordon, J.I. J. Biol. Chem. (1993)
- Biochemical studies of Saccharomyces cerevisiae myristoyl-coenzyme A:protein N-myristoyltransferase mutants. Zhang, L., Jackson-Machelski, E., Gordon, J.I. J. Biol. Chem. (1996)
- Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans. Lodge, J.K., Johnson, R.L., Weinberg, R.A., Gordon, J.I. J. Biol. Chem. (1994)
- A role for Saccharomyces cerevisiae fatty acid activation protein 4 in regulating protein N-myristoylation during entry into stationary phase. Ashrafi, K., Farazi, T.A., Gordon, J.I. J. Biol. Chem. (1998)
- Analysis of the compartmentalization of myristoyl-CoA:protein N-myristoyltransferase in Saccharomyces cerevisiae. Knoll, L.J., Levy, M.A., Stahl, P.D., Gordon, J.I. J. Biol. Chem. (1992)
- Purification and characterization of yeast myristoyl CoA:protein N-myristoyltransferase. Towler, D.A., Adams, S.P., Eubanks, S.R., Towery, D.S., Jackson-Machelski, E., Glaser, L., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Crystal structure of the anti-fungal target N-myristoyl transferase. Weston, S.A., Camble, R., Colls, J., Rosenbrock, G., Taylor, I., Egerton, M., Tucker, A.D., Tunnicliffe, A., Mistry, A., Mancia, F., de la Fortelle, E., Irwin, J., Bricogne, G., Pauptit, R.A. Nat. Struct. Biol. (1998)
- Myristoylation. Boutin, J.A. Cell. Signal. (1997)
- Isolation of a Saccharomyces cerevisiae long chain fatty acyl:CoA synthetase gene (FAA1) and assessment of its role in protein N-myristoylation. Duronio, R.J., Knoll, L.J., Gordon, J.I. J. Cell Biol. (1992)
- Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism. Rudnick, D.A., Rocque, W.J., McWherter, C.A., Toth, M.V., Jackson-Machelski, E., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Transcription of INO2 and INO4 is regulated by the state of protein N-myristoylation in Saccharomyces cerevisiae. Cok, S.J., Martin, C.G., Gordon, J.I. Nucleic Acids Res. (1998)
- Comparative analysis of the beta transducin family with identification of several new members including PWP1, a nonessential gene of Saccharomyces cerevisiae that is divergently transcribed from NMT1. Duronio, R.J., Gordon, J.I., Boguski, M.S. Proteins (1992)
- Isothermal titration calorimetric studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Determinants of binding energy and catalytic discrimination among acyl-CoA and peptide ligands. Bhatnagar, R.S., Jackson-Machelski, E., McWherter, C.A., Gordon, J.I. J. Biol. Chem. (1994)
- Crystallographic phasing of myristoyl-CoA-protein N-myristoyltransferase using an iodinated analog of myristoyl-CoA. Fütterer , K., Murray , C.L., Bhatnagar , R.S., Gokel , G.W., Gordon , J.I., Waksman , G. Acta Crystallogr. D Biol. Crystallogr. (2001)
- Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites. Price, H.P., Menon, M.R., Panethymitaki, C., Goulding, D., McKean, P.G., Smith, D.F. J. Biol. Chem. (2003)