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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

DXG-TP     [[[(2R,4R)-4-(2-amino-6-oxo- 3H-purin-9-yl)...

Synonyms: CHEMBL261773, AC1L9TRD
 
 
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Disease relevance of DXG-TP

  • By contrast, the double DHBV polymerase mutant was sensitive to DXG-TP and DAPD-TP [1].
  • The A62V mutation significantly increased the rate of incorporation (k(pol)) for both dGTP (3-fold) and DXG-TP (7.9-fold), while the binding affinity of A62V HIV-1 RT for DXG-TP was decreased 14-fold [2].

References

  1. Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses. Seignères, B., Pichoud, C., Martin, P., Furman, P., Trépo, C., Zoulim, F. Hepatology (2002) [Pubmed]
  2. Effects of HIV Q151M-associated multi-drug resistance mutations on the activities of (-)-beta-D-1',3'-dioxolan guanine. Feng, J.Y., Myrick, F., Selmi, B., Deval, J., Canard, B., Borroto-Esoda, K. Antiviral Res. (2005) [Pubmed]
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