Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1LA62X [3-[hydroxy-[[3-hydroxy-5-(5- methyl-2,4...

Synonyms: 5'-TT-3'

Doss, R.M. et al., Vogan, K.J. et al.

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High impact information on AIDS-097602

This new consensus differs at six out of eight positions from the C-terminal subdomain recognition motif present in the parent CD19-2/A sequence, and includes a 5'-TT-3' dinucleotide at base pairs 15 and 16 that promotes high affinity binding by both Pax-3 isoforms [1].
A new set of end-cap heterocycle dimers, oxazole-hydroxybenzimidazole (No-Hz) and chlorothiophene-hydroxybenzimidazole (Ct-Hz), paired with Py-Py are shown to bind contiguous base pairs of DNA in the minor groove, specifically 5'-GT-3' and 5'-TT-3', with high affinity and selectivity [2].

References

The C-terminal subdomain makes an important contribution to the DNA binding activity of the Pax-3 paired domain. Vogan, K.J., Gros, P. J. Biol. Chem. (1997) [Pubmed]
Programmable oligomers for minor groove DNA recognition. Doss, R.M., Marques, M.A., Foister, S., Chenoweth, D.M., Dervan, P.B. J. Am. Chem. Soc. (2006) [Pubmed]

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