Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1LANJN tert-butyl 3-[(2S,3S)-3-[[(2S)-3...

Synonyms:

Cardounel, A.J. et al., Manfredini, S. et al.

Manfredini, Vertuani, Manfredi, Rossoni, Calviello, Palozza,

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High impact information on MIXTURE OF STEREOISOMERS

Dose-ranging revealed that the statistical mixture of stereoisomers of the novel derivative, at millimolar (mM) concentrations, could nearly completely eliminate the superoxide anion signal generated in the activated human neutrophil assay [1].

Analytical, diagnostic and therapeutic context of MIXTURE OF STEREOISOMERS

Moreover, the mixture of stereoisomers 11a-d also proved to be effective in preventing damage induced by reperfusion on isolated rabbit heart, in particular at the higher concentration of 300 microM [2].

References

Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: Relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron paramagnetic resonance imaging. Cardounel, A.J., Dumitrescu, C., Zweier, J.L., Lockwood, S.F. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Novel antioxidant agents deriving from molecular combinations of vitamins C and E analogues: 3,4-dihydroxy-5(R). Manfredini, S., Vertuani, S., Manfredi, B., Rossoni, G., Calviello, G., Palozza, P. Bioorg. Med. Chem. (2000) [Pubmed]

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