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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Neutrophils


Psychiatry related information on Neutrophils


High impact information on Neutrophils


Chemical compound and disease context of Neutrophils


Biological context of Neutrophils


Anatomical context of Neutrophils

  • Administration of recombinant GM-CSF resulted in dose-dependent increases in circulating leukocytes and in increases in circulating neutrophils, eosinophils, and monocytes [25].
  • The serums of five patients with idiopathic neutropeniaopsonized normal neutrophils, causing them to be ingested by rabbit macrophages or else to activate glucose oxidation rates of other normal neutrophils by at least twice the rate of controls [26].
  • The adherence of neutrophils to bovine endothelial-cell monolayers pretreated with leukotriene B4 was inhibited completely, and their average chemotactic response to leukotriene B4 was inhibited by 70 per cent, as compared with values determined before the diet was begun and six weeks after its discontinuation [27].
  • F(ab')2 fragments of a monoclonal antibody, 25E11, raised against activated large granular lymphocytes, inhibited killing by natural killer cells, blocked the binding of fibronectin-coated particles by monocytes, and stimulated neutrophils to exhibit increased antibody-dependent killing [28].
  • Results. Treatment with granulocyte CSF accelerated the recovery of neutrophils significantly (P less than 0.01), shortening it by about a week, but it had no effect on platelet recovery [29].

Associations of Neutrophils with chemical compounds


Gene context of Neutrophils

  • Granulocyte colony-stimulating factor (G-CSF) is a cytokine that regulates the proliferation and differentiation of neutrophils [35].
  • Thus, matrilysin-mediated shedding of syndecan-1/KC complexes from the mucosal surface directs and confines neutrophil influx to sites of injury [4].
  • Cells transfected with VCAM-1 bind the human leukemia lines Jurkat, Ramos, Raji, HL60, and THP1, but not peripheral blood neutrophils [36].
  • In matrilysin null mice, neutrophils remained confined in the interstitium of injured lungs and did not advance into the alveolar space [4].
  • EPIs inhibit the growth of epithelial cells but induce them to secrete the neutrophil attractant IL-8, while PEPI blocks neutrophil activation by tumor necrosis factor, preventing release of oxidants and proteases [37].

Analytical, diagnostic and therapeutic context of Neutrophils


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  3. Genetic variants of chronic granulomatous disease: prevalence of deficiencies of two cytosolic components of the NADPH oxidase system. Clark, R.A., Malech, H.L., Gallin, J.I., Nunoi, H., Volpp, B.D., Pearson, D.W., Nauseef, W.M., Curnutte, J.T. N. Engl. J. Med. (1989) [Pubmed]
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  5. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Helgadottir, A., Manolescu, A., Thorleifsson, G., Gretarsdottir, S., Jonsdottir, H., Thorsteinsdottir, U., Samani, N.J., Gudmundsson, G., Grant, S.F., Thorgeirsson, G., Sveinbjornsdottir, S., Valdimarsson, E.M., Matthiasson, S.E., Johannsson, H., Gudmundsdottir, O., Gurney, M.E., Sainz, J., Thorhallsdottir, M., Andresdottir, M., Frigge, M.L., Topol, E.J., Kong, A., Gudnason, V., Hakonarson, H., Gulcher, J.R., Stefansson, K. Nat. Genet. (2004) [Pubmed]
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  9. Neutrophil beta2-adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controls. Gurguis, G.N., Andrews, R., Antai-Otong, D., Vo, S.P., Blakeley, J.E., Orsulak, P.J., Rush, A.J. Psychopharmacology (Berl.) (1999) [Pubmed]
  10. Hematopoiesis in the liver and marrow of human fetuses at 5 to 16 weeks postconception: quantitative assessment of macrophage and neutrophil populations. Slayton, W.B., Juul, S.E., Calhoun, D.A., Li, Y., Braylan, R.C., Christensen, R.D. Pediatr. Res. (1998) [Pubmed]
  11. Interleukin-1 receptor antagonist: role in biology. Arend, W.P., Malyak, M., Guthridge, C.J., Gabay, C. Annu. Rev. Immunol. (1998) [Pubmed]
  12. Protease-activated receptors: contribution to physiology and disease. Ossovskaya, V.S., Bunnett, N.W. Physiol. Rev. (2004) [Pubmed]
  13. M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage. Herwald, H., Cramer, H., Mörgelin, M., Russell, W., Sollenberg, U., Norrby-Teglund, A., Flodgaard, H., Lindbom, L., Björck, L. Cell (2004) [Pubmed]
  14. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Balbín, M., Fueyo, A., Tester, A.M., Pendás, A.M., Pitiot, A.S., Astudillo, A., Overall, C.M., Shapiro, S.D., López-Otín, C. Nat. Genet. (2003) [Pubmed]
  15. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Yan, J.J., Jung, J.S., Lee, J.E., Lee, J., Huh, S.O., Kim, H.S., Jung, K.C., Cho, J.Y., Nam, J.S., Suh, H.W., Kim, Y.H., Song, D.K. Nat. Med. (2004) [Pubmed]
  16. Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids. Young, J.D., Lawrence, A.J., MacLean, A.G., Leung, B.P., McInnes, I.B., Canas, B., Pappin, D.J., Stevenson, R.D. Nat. Med. (1999) [Pubmed]
  17. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Coxon, A., Rieu, P., Barkalow, F.J., Askari, S., Sharpe, A.H., von Andrian, U.H., Arnaout, M.A., Mayadas, T.N. Immunity (1996) [Pubmed]
  18. Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureus. Tsuda, Y., Takahashi, H., Kobayashi, M., Hanafusa, T., Herndon, D.N., Suzuki, F. Immunity (2004) [Pubmed]
  19. Decreased spleen size and increased neutrophils in patients with Felty syndrome. Effects of gold sodium thiomalate therapy. Hurd, E.R., Cheatum, D.E. JAMA (1976) [Pubmed]
  20. A neutrophil disorder induced by capnocytophaga, a dental micro-organism. Shurin, S.B., Socransky, S.S., Sweeney, E., Stossel, T.P. N. Engl. J. Med. (1979) [Pubmed]
  21. Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Bokoch, G.M., Gilman, A.G. Cell (1984) [Pubmed]
  22. Increased expression of an adhesion-promoting surface glycoprotein in the granulocytopenia of hemodialysis. Arnaout, M.A., Hakim, R.M., Todd, R.F., Dana, N., Colten, H.R. N. Engl. J. Med. (1985) [Pubmed]
  23. alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Berlin, C., Bargatze, R.F., Campbell, J.J., von Andrian, U.H., Szabo, M.C., Hasslen, S.R., Nelson, R.D., Berg, E.L., Erlandsen, S.L., Butcher, E.C. Cell (1995) [Pubmed]
  24. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Weathington, N.M., van Houwelingen, A.H., Noerager, B.D., Jackson, P.L., Kraneveld, A.D., Galin, F.S., Folkerts, G., Nijkamp, F.P., Blalock, J.E. Nat. Med. (2006) [Pubmed]
  25. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. Groopman, J.E., Mitsuyasu, R.T., DeLeo, M.J., Oette, D.H., Golde, D.W. N. Engl. J. Med. (1987) [Pubmed]
  26. Autoimmune neutropenia. Boxer, L.A., Greenberg, M.S., Boxer, G.J., Stossel, T.P. N. Engl. J. Med. (1975) [Pubmed]
  27. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. Lee, T.H., Hoover, R.L., Williams, J.D., Sperling, R.I., Ravalese, J., Spur, B.W., Robinson, D.R., Corey, E.J., Lewis, R.A., Austen, K.F. N. Engl. J. Med. (1985) [Pubmed]
  28. The IIb-IIIa glycoprotein complex that mediates platelet aggregation is directly implicated in leukocyte adhesion. Burns, G.F., Cosgrove, L., Triglia, T., Beall, J.A., López, A.F., Werkmeister, J.A., Begley, C.G., Haddad, A.P., d'Apice, A.J., Vadas, M.A. Cell (1986) [Pubmed]
  29. Effect of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia. Ohno, R., Tomonaga, M., Kobayashi, T., Kanamaru, A., Shirakawa, S., Masaoka, T., Omine, M., Oh, H., Nomura, T., Sakai, Y. N. Engl. J. Med. (1990) [Pubmed]
  30. Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate. Boxer, L.A., Watanabe, A.M., Rister, M., Besch, H.R., Allen, J., Baehner, R.L. N. Engl. J. Med. (1976) [Pubmed]
  31. Hydroxyl radical formation in neutrophils. Britigan, B.E., Cohen, M.S., Rosen, G.M. N. Engl. J. Med. (1988) [Pubmed]
  32. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Picker, L.J., Warnock, R.A., Burns, A.R., Doerschuk, C.M., Berg, E.L., Butcher, E.C. Cell (1991) [Pubmed]
  33. Protection of granulocytes by vitamin E in glutathione synthetase deficiency. Boxer, L.A., Oliver, J.M., Spielberg, S.P., Allen, J.M., Schulman, J.D. N. Engl. J. Med. (1979) [Pubmed]
  34. Effect of lithium on neutrophil mass and production. Rothstein, G., Clarkson, D.R., Larsen, W., Grosser, B.I., Athens, J.W. N. Engl. J. Med. (1978) [Pubmed]
  35. Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Fukunaga, R., Ishizaka-Ikeda, E., Nagata, S. Cell (1993) [Pubmed]
  36. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Osborn, L., Hession, C., Tizard, R., Vassallo, C., Luhowskyj, S., Chi-Rosso, G., Lobb, R. Cell (1989) [Pubmed]
  37. Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Zhu, J., Nathan, C., Jin, W., Sim, D., Ashcroft, G.S., Wahl, S.M., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Wright, C.D., Ding, A. Cell (2002) [Pubmed]
  38. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. Falk, R.J., Jennette, J.C. N. Engl. J. Med. (1988) [Pubmed]
  39. An acquired chemotactic defect in neutrophils from patients receiving interleukin-2 immunotherapy. Klempner, M.S., Noring, R., Mier, J.W., Atkins, M.B. N. Engl. J. Med. (1990) [Pubmed]
  40. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Sekido, N., Mukaida, N., Harada, A., Nakanishi, I., Watanabe, Y., Matsushima, K. Nature (1993) [Pubmed]
  41. The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex. Dinauer, M.C., Orkin, S.H., Brown, R., Jesaitis, A.J., Parkos, C.A. Nature (1987) [Pubmed]
  42. The Ets-1 transcription factor is required for the development of natural killer cells in mice. Barton, K., Muthusamy, N., Fischer, C., Ting, C.N., Walunas, T.L., Lanier, L.L., Leiden, J.M. Immunity (1998) [Pubmed]
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