Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

A(Rp)ApA (2R,3R,4S,5R)-2-(6- aminopurin-9-yl)-5...

Synonyms: A(Sp)ApA, AC1L9U5K, P-Thioadenylyl-2'-5'-adenosine

This record was replaced with 501014.

Sobol, R.W. et al.

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The first and second internucleotide linkages are critical for activation of recombinant, human RNase L; A(Rp)ApA, A(Sp)ApA and ApA(Rp)A are agonists (IC50 = 2 x 10(-7), 2 x 10(-6) and 8 x 10(-6) M); ApA(Sp)A is an antagonist [1].

References

Inhibition of HIV-1 replication and activation of RNase L by phosphorothioate/phosphodiester 2',5'-oligoadenylate derivatives. Sobol, R.W., Henderson, E.E., Kon, N., Shao, J., Hitzges, P., Mordechai, E., Reichenbach, N.L., Charubala, R., Schirmeister, H., Pfleiderer, W. J. Biol. Chem. (1995) [Pubmed]

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