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Chemical Compound Review

ApA(Rp)A     (2R,3R,4S,5R)-2-(6- aminopurin-9-yl)-5...

Synonyms: ApA(Sp)A, AC1L9U5Q
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Disease relevance of

  • HIV-1 infection results in enhanced uptake and accumulation of ApA(Rp)A and ApA(Sp)A (7- and 10-fold, respectively) [1].

High impact information on


  1. Inhibition of HIV-1 replication and activation of RNase L by phosphorothioate/phosphodiester 2',5'-oligoadenylate derivatives. Sobol, R.W., Henderson, E.E., Kon, N., Shao, J., Hitzges, P., Mordechai, E., Reichenbach, N.L., Charubala, R., Schirmeister, H., Pfleiderer, W. J. Biol. Chem. (1995) [Pubmed]
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