Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

ApA(Rp)A (2R,3R,4S,5R)-2-(6- aminopurin-9-yl)-5...

Synonyms: ApA(Sp)A, AC1L9U5Q

This record was replaced with 501016.

Sobol, R.W. et al.

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Disease relevance of

HIV-1 infection results in enhanced uptake and accumulation of ApA(Rp)A and ApA(Sp)A (7- and 10-fold, respectively) [1].

High impact information on

The second and third internucleotide linkages are crucial for activation of murine RNase L; ApA(Rp)A, ApA(Rp)ApA, and ApApA(Rp)A are agonists (IC50 = 5 x 10(-7) M); ApA(Sp)A, ApA(Sp)ApA, and ApApA(Sp)A are antagonists [1].

References

Inhibition of HIV-1 replication and activation of RNase L by phosphorothioate/phosphodiester 2',5'-oligoadenylate derivatives. Sobol, R.W., Henderson, E.E., Kon, N., Shao, J., Hitzges, P., Mordechai, E., Reichenbach, N.L., Charubala, R., Schirmeister, H., Pfleiderer, W. J. Biol. Chem. (1995) [Pubmed]

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