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Chemical Compound Review

CCRIS 4069     N-[4-[4-(hydroxyamino) phenyl]phenyl]ethana...

Synonyms: AG-G-80798, AC1L1AXG, LS-10764, CTK5D4724, 71609-23-9, ...
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High impact information on CCRIS 4069

  • The same carcinogen:DNA adduct found in rat and mouse liver was prepared synthetically by: (a) hydrolysis of calf thymus DNA reacted with N-hydroxy-N'-acetylbenzidine at pH 5; and (b) reaction of N-acetoxy-N,N'-diacetylbenzidine with deoxyguanosine and subsequent selective deacetylation of the product with methanolic ammonia [1].


  1. Covalent binding of benzidine and N-acetylbenzidine to DNA at the C-8 atom of deoxyguanosine in vivo and in vitro. Martin, C.N., Beland, F.A., Roth, R.W., Kadlubar, F.F. Cancer Res. (1982) [Pubmed]
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