Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PSYCHOSINE (2R,3R,4S,5R,6R)-2- [(E,2S,3R)-2-amino-3...

Synonyms: SureCN242696, CHEBI:16874, P9256_SIGMA, AC1NQX21, C01747, ...

Sugiyama, E. et al., Farrer, R.G. et al.

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Disease relevance of PSYCHOSINE

The cell numbers of three mouse neuroblastoma cell lines were decreased upon incubation with lysosphingolipids in the following order of effectiveness: lysosulfatide (lysoCS) greater than psychosine (Ps) greater than sphingosylphosphocholine (SPC) [1].

High impact information on PSYCHOSINE

Incubation of cells with 100 microM GalSph and labeled fatty acids of various chain lengths revealed that the acylation of GalSph was specific for medium chain (C16-C18) nonhydroxy fatty acids, suggesting that this was an enzyme-mediated reaction [2].

References

Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines. Sugiyama, E., Uemura, K., Hara, A., Taketomi, T. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
Acylation of exogenous glycosylsphingosines by intact neuroblastoma (NCB-20) cells. Farrer, R.G., Dawson, G. J. Biol. Chem. (1990) [Pubmed]

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