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Chemical Compound Review:

Bellidifolin 1,5,8-trihydroxy-3-methoxy- xanthen-9-one

Synonyms: Bellidifoline, Bellidifolium, AC1NQYR7, CHEMBL185776, CCRIS 5471, ...

Hirakawa, K. et al., Rana, V.S. et al.

Rana, Rawat,

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High impact information on CCRIS 5471

In this study, the chemopreventive action of xanthone (XAN) derivatives (bellidifolin [BEL], gentiacaulein [GEN], norswertianin [NOR] and swerchirin [SWE]) on DNA damage photosensitized by riboflavin was demonstrated using [32P]-5'-end-labeled DNA fragments obtained from genes relevant to human cancer [1].
Both the acetone and MeOH extracts, as well as the known constituents ursolic acid (5) and 1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one (6) exhibited potent antioxidant activities in different biological assays (Table 2) [2].

References

Chemopreventive action of xanthone derivatives on photosensitized DNA damage. Hirakawa, K., Yoshida, M., Nagatsu, A., Mizukami, H., Rana, V., Rawat, M.S., Oikawa, S., Kawanishi, S. Photochem. Photobiol. (2005) [Pubmed]
A new xanthone glycoside and antioxidant constituents from the rhizomes of Swertia speciosa. Rana, V.S., Rawat, M.S. Chem. Biodivers. (2005) [Pubmed]

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