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Chemical Compound Review:

Getiacaulein 2,8-dihydroxy-1,6-dimethoxy- xanthen-9-one

Synonyms: Gentiacaulein, AC1NQYS1, CHEMBL467590, NSC-661743, NSC661743, ...

Chericoni, S. et al., Tomić, M. et al.

Tomić, Tovilović, Butorović, Krstić, Janković, Aljancić, Menković,

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High impact information on C10064

In conclusion, gentiacaulein and gentiakochianin seem to be the compounds responsible for the vasorelaxing properties of the crude extract of Gentiana kochiana roots [1].
However, the extract and gentiacaulein strongly inhibited rat microsomal MAO A (IC50=0.22 microg/ml and 0.49 microM, respectively) [2].

References

The xanthones gentiacaulein and gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana. Chericoni, S., Testai, L., Calderone, V., Flamini, G., Nieri, P., Morelli, I., Martinotti, E. Planta Med. (2003) [Pubmed]
Neuropharmacological evaluation of diethylether extract and xanthones of Gentiana kochiana. Tomić, M., Tovilović, G., Butorović, B., Krstić, D., Janković, T., Aljancić, I., Menković, N. Pharmacol. Biochem. Behav. (2005) [Pubmed]

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