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Disease relevance of Gentiana

  • Gentiopicroside (GPS), a main bitter secoiridoid constituent of roots of Gentiana macrophylla Pall., was tested for therapeutic effects on the two hepatic injury models, the CCl4-induced and lipopolysaccharide (LPS)/bacillus Calmette-Guerin (BCG)-induced hepatitides [1].
  • Cofactor requirement was determined for the heterologous expressed phytoene desaturases from the cyanobacterium Synechococcus and the higher plant Gentiana lutea [2].

High impact information on Gentiana


Biological context of Gentiana

  • A full-length cDNA encoding the anthocyanin 5-aromatic acyltransferase (5AT) (EC that acylates the glucose bound at the 5-position of anthocyanidin 3,5-diglucoside was isolated from petals of Gentiana triflora on the basis of the amino acid sequence of the purified enzyme [5].

Anatomical context of Gentiana


Associations of Gentiana with chemical compounds

  • The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity [9].
  • The xanthones gentiacaulein and gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana [10].
  • In conclusion, gentiacaulein and gentiakochianin seem to be the compounds responsible for the vasorelaxing properties of the crude extract of Gentiana kochiana roots [10].
  • Full length cDNA clones of flavonoid 3',5'-hydroxylase, dihydroflavonol 4-reductase and flavonoid 3-glucosyltransferase were cloned from petals of Gentiana triflora [11].
  • A new triterpenoid, 12-ursene-3beta, 11alpha-diol 3-O-palmitate (1), has been isolated from the rhizomes and roots of Gentiana lutea, together with the artificial diene derivative, 9 (11), 12-ursadien-3beta-ol 3-O-palmitate (1a) and five known compounds (3-7) [12].

Gene context of Gentiana


Analytical, diagnostic and therapeutic context of Gentiana


  1. Suppression of chemically and immunologically induced hepatic injuries by gentiopicroside in mice. Kondo, Y., Takano, F., Hojo, H. Planta Med. (1994) [Pubmed]
  2. Bleaching herbicide norflurazon inhibits phytoene desaturase by competition with the cofactors. Breitenbach, J., Zhu, C., Sandmann, G. J. Agric. Food Chem. (2001) [Pubmed]
  3. Consistent transcriptional silencing of 35S-driven transgenes in gentian. Mishiba, K., Nishihara, M., Nakatsuka, T., Abe, Y., Hirano, H., Yokoi, T., Kikuchi, A., Yamamura, S. Plant J. (2005) [Pubmed]
  4. Biochemical and molecular characterization of a novel UDP-glucose:anthocyanin 3'-O-glucosyltransferase, a key enzyme for blue anthocyanin biosynthesis, from gentian. Fukuchi-Mizutani, M., Okuhara, H., Fukui, Y., Nakao, M., Katsumoto, Y., Yonekura-Sakakibara, K., Kusumi, T., Hase, T., Tanaka, Y. Plant Physiol. (2003) [Pubmed]
  5. cDNA cloning, gene expression and subcellular localization of anthocyanin 5-aromatic acyltransferase from Gentiana triflora. Fujiwara, H., Tanaka, Y., Yonekura-Sakakibara, K., Fukuchi-Mizutani, M., Nakao, M., Fukui, Y., Yamaguchi, M., Ashikari, T., Kusumi, T. Plant J. (1998) [Pubmed]
  6. Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts. Oztürk, N., Korkmaz, S., Oztürk, Y., Başer, K.H. Planta Med. (2006) [Pubmed]
  7. Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea. Rojas, A., Bah, M., Rojas, J.I., Gutiérrez, D.M. Planta Med. (2000) [Pubmed]
  8. Effects of Gentiana lutea ssp. symphyandra on the central nervous system in mice. Oztürk, N., Başer, K.H., Aydin, S., Oztürk, Y., Caliş, I. Phytotherapy research : PTR. (2002) [Pubmed]
  9. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Urbain, A., Marston, A., Queiroz, E.F., Ndjoko, K., Hostettmann, K. Planta Med. (2004) [Pubmed]
  10. The xanthones gentiacaulein and gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana. Chericoni, S., Testai, L., Calderone, V., Flamini, G., Nieri, P., Morelli, I., Martinotti, E. Planta Med. (2003) [Pubmed]
  11. Molecular and biochemical characterization of three anthocyanin synthetic enzymes from Gentiana triflora. Tanaka, Y., Yonekura, K., Fukuchi-Mizutani, M., Fukui, Y., Fujiwara, H., Ashikari, T., Kusumi, T. Plant Cell Physiol. (1996) [Pubmed]
  12. Studies on the constituents of Gentiana species. II. A new triterpenoid, and (S)-(+)- and (R)-(-)-gentiolactones from Gentiana lutea. Kakuda, R., Machida, K., Yaoita, Y., Kikuchi, M., Kikuchi, M. Chem. Pharm. Bull. (2003) [Pubmed]
  13. Isoorientin-6"-O-glucoside, a water-soluble antioxidant isolated from Gentiana arisanensis. Ko, F.N., Chu, C.C., Lin, C.N., Chang, C.C., Teng, C.M. Biochim. Biophys. Acta (1998) [Pubmed]
  14. Antiproliferative Activity of Root Extract from Gentian Plant (Gentiana triflora) on Cultured and Implanted Tumor Cells. Matsukawa, K., Ogata, M., Hikage, T., Minami, H., Shimotai, Y., Saitoh, Y., Yamashita, T., Ouchi, A., Tsutsumi, R., Fujioka, T., Tsutsumi, K. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
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