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Chemical Compound Review:

geroquinol 2-[(2E)-3,7-dimethylocta- 2,6...

Synonyms: Gerochinolo, Geroquinolum, CHEMBL459815, SureCN557012, CPD-9319, ...

Ippen, H., Reynolds, G. et al., Yamamoto, H. et al.

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Disease relevance of Geranylhydroquinone

Geranyl(hydro)quinone and related substances, including the geranylhydroquinone geroquinol (INN), which has been introduced as a radioprotective agent, are potent allergens and probably are more often the cause of allergic eczema than is apparent from the literature [1].

High impact information on Geranylhydroquinone

Geranylhydroquinone 3"-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures [2].
The major contact allergen of Phacelia crenulata (Hydrophyllaceae) has been identified as geranylhydroquinone [3].
A maximization test of geranylhydroquinone showed this to be a potent sensitizer comparable in degree to poison oak/ivy urushiol [3].

References

Contact allergy to Phacelia spp. (Hydrophyllaceae). Ippen, H. Dermatologic clinics. (1990) [Pubmed]
Geranylhydroquinone 3"-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures. Yamamoto, H., Inoue, K., Li, S.M., Heide, L. Planta (2000) [Pubmed]
A potent contact allergen of Phacelia (Hydrophyllaceae). Reynolds, G., Epstein, W., Terry, D., Rodriguez, E. Contact Derm. (1980) [Pubmed]

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