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Disease relevance of Eczema


High impact information on Eczema

  • This relation with the serum IgE level was not explained by a concomitant diagnosis of allergic rhinitis or eczema [6].
  • Editorial: Methylene blue for eczema herpeticum [7].
  • 2. We aimed to identify variants of MCC and another gene within this complex, and assess whether there is a genetic association between variants of MCC and atopic disorders-particularly eczema [2].
  • Latex gloves as a cause of inflammation and eczema [8].
  • The concentration of IgE antibodies to the mite body was higher in those with eczema than in those with asthma, but the concentrations of IgE antibodies to the faecal allergen were not significantly different [9].

Chemical compound and disease context of Eczema

  • Specific IgE complexes and symptoms of asthma and eczema were produced in two allergic patients by oral challenge with food allergen [3].
  • Treatment of eczema herpeticum with oral acyclovir [10].
  • The effect of dexamethasone (DM) on de novo in vitro total IgE synthesis by blood mononuclear cells (MNC) was studied in atopic patients with eczema and in nonatopic control subjects [11].
  • Lenticular complications of long-term steroid therapy in children with asthma and eczema [12].
  • Depressed chemotaxis was not related to the presence of infection, to the serum IgE level, or to the severity of the eczema, and it could not be produced in vitro by incubating normal cells with histamine or IgE myeloma [13].

Biological context of Eczema


Anatomical context of Eczema


Gene context of Eczema

  • The Wiskott-Aldrich syndrome is an inherited X-linked immunodeficiency characterized by thrombocytopenia, eczema, and a tendency toward lymphoid malignancy [20].
  • Concentrations of immunoreactive SP, NKA, and CGRP were measured in extracts of the eczema ears (n = 26), whereas extracts of the opposite ears were used as controls [21].
  • It was also expressed in lichen planus, chronic eczema, cutaneous squamous cell cancers, and during normal wound repair when IFI27 was found in the proliferating subpopulation of keratinocytes [22].
  • Skin prick test-negative children with eczema produced higher levels of IL-10 than skin prick test-positive children [23].
  • Upon stimulation with Der f peripheral blood mononuclear cells from patients proliferated in a B7-dependent (CD80- and CD86-dependent) manner, while those from the patients with negative scores, nonatopic eczematous dermatitis patients or normal individuals, did not [24].

Analytical, diagnostic and therapeutic context of Eczema

  • The aim of the present retrospective study was to estimate the incidence rate of self-reported hand eczema in a sample from the general population and to study the relation of this to age, sex, and atopy [25].
  • Children who underwent adenoidectomy and/or tonsillectomy before the age of 8 years were not more likely to develop asthma, AR, or eczema at the age of 21 years than children who did not; RR 0.93 (95% confidence limits (CL) 0.52-1.64), RR 0.94 (CL 0.68-1.30), and RR 1.00 (CL 0.59-1.68), respectively [26].
  • Data from epidemiological studies conducted in several countries worldwide have revealed that the prevalences of allergic conditions, including allergic rhinitis, asthma and eczema, have increased from the 1940s/50s to the 1990s [27].
  • In the other six patients, the clinical picture was local eczema, and the patch tests were all positive with Mercurochrome and the inorganic mercuric derivatives [28].
  • Hypersensitivity to bacteria in eczema. I. Bacterial culture, skin tests and immunofluorescent detection of immunoglobulins and bacterial antigens [29].


  1. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Derry, J.M., Ochs, H.D., Francke, U. Cell (1994) [Pubmed]
  2. Association between genetic variants of mast-cell chymase and eczema. Mao, X.Q., Shirakawa, T., Yoshikawa, T., Yoshikawa, K., Kawai, M., Sasaki, S., Enomoto, T., Hashimoto, T., Furuyama, J., Hopkin, J.M., Morimoto, K. Lancet (1996) [Pubmed]
  3. Production of IgE complexes by allergen challenge in atopic patients and the effect of sodium cromoglycate. Brostoff, J., Carini, C., Wraith, D.G., Johns, P. Lancet (1979) [Pubmed]
  4. Exacerbation of eczema by formalin-containing hepatitis B vaccine in formaldehyde-allergic patient. Ring, J. Lancet (1986) [Pubmed]
  5. Phenytoin, leukopenia, and remission of eczema. Fisher, D.E. Ann. Intern. Med. (1987) [Pubmed]
  6. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. Sears, M.R., Burrows, B., Flannery, E.M., Herbison, G.P., Hewitt, C.J., Holdaway, M.D. N. Engl. J. Med. (1991) [Pubmed]
  7. Editorial: Methylene blue for eczema herpeticum. Chang, T.W. JAMA (1975) [Pubmed]
  8. Latex gloves as a cause of inflammation and eczema. Garred, P., Våge, D.I., Mollnes, T.E., Harboe, M. Lancet (1990) [Pubmed]
  9. Does natural sensitisation in eczema occur through the skin? Carswell, F., Thompson, S. Lancet (1986) [Pubmed]
  10. Treatment of eczema herpeticum with oral acyclovir. Niimura, M., Nishikawa, T. Am. J. Med. (1988) [Pubmed]
  11. Effect of dexamethasone on de novo IgE synthesis by human blood lymphocytes. Hemady, Z., Gellis, S., Chambers, M., Rocklin, R.E. J. Allergy Clin. Immunol. (1985) [Pubmed]
  12. Lenticular complications of long-term steroid therapy in children with asthma and eczema. Sevel, D., Weinberg, E.G., Van Niekerk, C.H. J. Allergy Clin. Immunol. (1977) [Pubmed]
  13. Abnormalities of leukotaxis in atopic dermatitis. Snyderman, R., Rogers, E., Buckley, R.H. J. Allergy Clin. Immunol. (1977) [Pubmed]
  14. Studies of the expression of the Wiskott-Aldrich syndrome protein. Stewart, D.M., Treiber-Held, S., Kurman, C.C., Facchetti, F., Notarangelo, L.D., Nelson, D.L. J. Clin. Invest. (1996) [Pubmed]
  15. A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis. Klunker, S., Trautmann, A., Akdis, M., Verhagen, J., Schmid-Grendelmeier, P., Blaser, K., Akdis, C.A. J. Immunol. (2003) [Pubmed]
  16. Decreased adrenergic responses in lymphocytes and granulocytes in atopic eczema. Busse, W.W., Lee, T.P. J. Allergy Clin. Immunol. (1976) [Pubmed]
  17. Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both. Jones, C.A., Holloway, J.A., Popplewell, E.J., Diaper, N.D., Holloway, J.W., Vance, G.H., Warner, J.A., Warner, J.O. J. Allergy Clin. Immunol. (2002) [Pubmed]
  18. Atypical Wiskott-Aldrich syndrome in a girl. Conley, M.E., Wang, W.C., Parolini, O., Shapiro, D.N., Campana, D., Siminovitch, K.A. Blood (1992) [Pubmed]
  19. Skin eosinophilia in patients with allergic and nonallergic asthma and atopic dermatitis. Bruijnzeel-Koomen, C., Storz, E., Menz, G., Bruijnzeel, P. J. Allergy Clin. Immunol. (1992) [Pubmed]
  20. Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. Tian, L., Nelson, D.L., Stewart, D.M. J. Biol. Chem. (2000) [Pubmed]
  21. Tachykinins and calcitonin gene-related peptide in oxazolone-induced allergic contact dermatitis in mice. Ek, L., Theodorsson, E. J. Invest. Dermatol. (1990) [Pubmed]
  22. Interferon alpha-inducible protein 27 (IFI27) is upregulated in psoriatic skin and certain epithelial cancers. Suomela, S., Cao, L., Bowcock, A., Saarialho-Kere, U. J. Invest. Dermatol. (2004) [Pubmed]
  23. Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis. Jenmalm, M.C., Aniansson-Zdolsek, H., Holt, P.G., Björkstén, B. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (2000) [Pubmed]
  24. Regulation of peripheral blood mononuclear cell responses to Dermatophagoides farinae by substance P in patients with atopic dermatitis. Yokote, R., Yagi, H., Furukawa, F., Takigawa, M. Arch. Dermatol. Res. (1998) [Pubmed]
  25. Incidence of hand eczema-a population-based retrospective study. Meding, B., Järvholm, B. J. Invest. Dermatol. (2004) [Pubmed]
  26. Adenoidectomy and/or tonsillectomy in childhood is not associated with atopic disease later in life. van Hattum, E.S., Balemans, W.A., Rovers, M.M., Zielhuis, G.A., Schilder, A.G., van der Ent, C.K. Clin. Exp. Allergy (2006) [Pubmed]
  27. Is allergy increasing?--early life influences. Howarth, P.H. Clin. Exp. Allergy (1998) [Pubmed]
  28. Mercurochrome allergy. Immediate and delayed hypersensitivity. Galindo, P.A., Feo, F., García, R., Gómez, E., Borja, J., Fernández, F. Allergy (1997) [Pubmed]
  29. Hypersensitivity to bacteria in eczema. I. Bacterial culture, skin tests and immunofluorescent detection of immunoglobulins and bacterial antigens. Welbourn, E., Champion, R.H., Parish, W.E. Br. J. Dermatol. (1976) [Pubmed]
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