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Chemical Compound Review

CHEMBL286364     N-[(1S)-3-methyl-1-[[(4S)-3- oxo-1-pyridin...

Synonyms: SB-357114, AC1NR9QT, Azepan-3-one compound 1
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Disease relevance of SB-357114


High impact information on SB-357114

  • To test this theory, we have produced a small molecule inhibitor of human cathepsin K, SB-357114, that potently and selectively inhibits this enzyme (Ki = 0.16 nM) [1].


  1. Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate. Stroup, G.B., Lark, M.W., Veber, D.F., Bhattacharyya, A., Blake, S., Dare, L.C., Erhard, K.F., Hoffman, S.J., James, I.E., Marquis, R.W., Ru, Y., Vasko-Moser, J.A., Smith, B.R., Tomaszek, T., Gowen, M. J. Bone Miner. Res. (2001) [Pubmed]
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